Chromosomal localization of human gene for histidyl-tRNA synthetase: clustering of genes encoding aminoacyl-tRNA synthetases on human chromosome 5

The gene encoding histidyl-tRNA synthetase was localized to human chromosome 5 using human-Chinese hamster ovary cell hybrids. Seven of the functionally related genes encoding the 20 different aminoacyl-tRNA synthetases have not been mapped in humans and four are located on a single chromosome, numb...

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Bibliographic Details
Published in:Somatic cell and molecular genetics 1986-09, Vol.12 (5), p.513-517
Main Authors: Wasmuth, J J, Carlock, L R
Format: Article
Language:English
Subjects:
Amino Acyl-tRNA Synthetases - genetics
Animals
Chromosome Mapping
Chromosomes, Human, Pair 5
Cricetinae
Cricetulus
Genes
Genetic Markers
Histidine-tRNA Ligase - genetics
Humans
Hybrid Cells
Karyotyping
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Summary:The gene encoding histidyl-tRNA synthetase was localized to human chromosome 5 using human-Chinese hamster ovary cell hybrids. Seven of the functionally related genes encoding the 20 different aminoacyl-tRNA synthetases have not been mapped in humans and four are located on a single chromosome, number 5, which represents less than 7% of the total genome. Thus, there appears to be significant clustering of this group of genes which may reflect their evolutionary relatedness or common factors involved in regulating their expression.
ISSN:0740-7750
1572-9931
DOI:10.1007/BF01539922