Italian multicenter study on reversible cerebral ischemic attacks. VI: Prognostic factors and follow-up results

A total of 462 patients (mean age 52 years) affected by reversible focal ischemic attacks (RIAs) were followed prospectively in 8 neurologic institutions in Italy for 4 years. All cases were evaluated with a cerebral angiography and 21% of angiograms were normal. At the end of the follow-up period t...

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Bibliographic Details
Published in:Stroke (1970) 1986-09, Vol.17 (5), p.842-848
Main Authors: CANDELISE, L, VIGOTTI, M, ARGENTINO, C, PASSERO, S, FIESCHI, C, BRAMBILLA, G. L, BONO, G, CONFORTI, P, DE ZANCHE, L, INZITARI, D, MARIANI, F, PRENCIPE, M
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Applied sciences
Biological and medical sciences
Epidemiologic Methods
Exact sciences and technology
Female
Follow-Up Studies
Humans
Ischemic Attack, Transient - complications
Ischemic Attack, Transient - epidemiology
Italy
Male
Medical sciences
Middle Aged
Neurology
Other techniques and industries
Prognosis
Time Factors
Vascular diseases and vascular malformations of the nervous system
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Summary:A total of 462 patients (mean age 52 years) affected by reversible focal ischemic attacks (RIAs) were followed prospectively in 8 neurologic institutions in Italy for 4 years. All cases were evaluated with a cerebral angiography and 21% of angiograms were normal. At the end of the follow-up period the cumulated probability for death, stroke, cardiac event and new RIA was respectively 7%, 8%, 3% and 36%. The predictive value of the baseline characteristics of this series was evaluated by a multifactorial analysis which showed that RIA and stroke (specific cerebrovascular risk) were more likely to develop in patients with a history of more than one RIA and in those in whom multiple vascular territories were involved. Moreover, previous myocardial infarction, intermittent claudication, angina pectoris, time elapsed since the first attack, and duration and severity of the attack itself were independently associated with general cardiovascular risk (death, stroke and myocardial infarction). We conclude that predictive factors, and thus also pathogenetic mechanisms, may be different for general cardiovascular risk and specific cerebrovascular risk in RIA patients.
ISSN:0039-2499
1524-4628
DOI:10.1161/01.STR.17.5.842