The effect of body weight on the calcitonin gene-related peptide-induced relaxation of guinea pig gallbladder strips

Calcitonin gene-related peptide (CGRP) has been reported to relax, in a concentration-dependent manner, cholecystokinin-induced tension in guinea pig gallbladder strips. It is now shown that this CGRP-induced relaxation is body weight dependent with the degree of relaxation inversely related to weig...

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Bibliographic Details
Published in:Regulatory peptides 1995-09, Vol.59 (1), p.97-101
Main Authors: Kline, Loren W., Pang, Peter K.T.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Body weight
Body Weight - physiology
Calcitonin gene-related peptide
Calcitonin Gene-Related Peptide - physiology
Cholecystokinin - pharmacology
Cholecystokinin octapeptide
Fundamental and applied biological sciences. Psychology
Gallbladder
Gallbladder - physiology
Guinea pig
Guinea Pigs
In Vitro Techniques
Liver. Bile. Biliary tracts
Muscle Contraction - drug effects
Muscle Relaxation - physiology
Relaxation
Vertebrates: digestive system
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Summary:Calcitonin gene-related peptide (CGRP) has been reported to relax, in a concentration-dependent manner, cholecystokinin-induced tension in guinea pig gallbladder strips. It is now shown that this CGRP-induced relaxation is body weight dependent with the degree of relaxation inversely related to weight. Radioimmunoassay demonstrated that the amount of CGRP in the gallbladder increased with body weight. Receptor binding showed that the number of binding sites and the affinity of the receptor decreased with increasing body weight. CGRP may play a role in the normal pattern of gallbladder contraction and relaxation. Decreased motility, even between periods of complete emptying, has been demonstrated to have a role in gallbladder diseases. The decreased sensitivity of the gallbladder to CGRP may explain the increase in abnormalities with age.
ISSN:0167-0115
1873-1686
DOI:10.1016/0167-0115(95)00078-P