Parenteral Influenza Vaccination Induces A Rapid Systemic And Local Immune Response

The kinetics of the local immune response in the upper respiratory tract to parenterally administered inactivated split trivalent influenza vaccine were examined in 19 healthy subjects. Influenza virus-specific antibody-secreting cells (ASC) could be detected as early as 2 days after vaccination in...

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Bibliographic Details
Published in:The Journal of infectious diseases 1995-01, Vol.171 (1), p.198-203
Main Authors: Brokstad, Karl A., Cox, Rebecca J., Olofsson, Jan, Jonsson, Roland, Haaheim, Lars R.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antibodies
Antibodies, Viral - biosynthesis
Antibodies, Viral - blood
Antibody-Producing Cells - immunology
B lymphocytes
Biological and medical sciences
Blood
Concise Communications
Female
Human viral diseases
Humans
Immune response
Immunoglobulin A - biosynthesis
Immunoglobulin A - blood
Immunoglobulin G - biosynthesis
Immunoglobulin G - blood
Immunoglobulin M - biosynthesis
Immunoglobulin M - blood
Infectious diseases
Influenza A virus - immunology
Influenza B virus - immunology
Influenza vaccines
Influenza Vaccines - administration & dosage
Influenza Vaccines - immunology
influenza virus
Injections, Subcutaneous
Kinetics
Lymphocytes
Male
Medical sciences
Orthomyxoviridae
Palatine Tonsil - immunology
Palatine tonsils
Saliva - immunology
Vaccination
Viral diseases
Viral diseases of the respiratory system and ent viral diseases
Viruses
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Description
Summary:The kinetics of the local immune response in the upper respiratory tract to parenterally administered inactivated split trivalent influenza vaccine were examined in 19 healthy subjects. Influenza virus-specific antibody-secreting cells (ASC) could be detected as early as 2 days after vaccination in peripheral blood and tonsils, with a peak at ∼1 week after vaccination and a decline to insignificant levels after 6 weeks. Circulating ASC produced IgG, IgA, and IgM, whereas ASC in tonsils produced mainly IgA and IgM. Influenza virus-specific antibodies were predominantly IgG and IgM in serum and IgA in oral fluid; they rose after 1 week and were elevated at 6 weeks. This may indicate a secretory involvement of the anti-influenza virus response in the upper respiratory tract. Parenteral influenza vaccination induced an immediate and significant immune response in both the upper respiratory tract and peripheral blood.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/171.1.198