Enhanced low density lipoprotein cholesterol reduction and cost-effectiveness by low-dose colestipol plus lovastatin combination therapy

A total of 96 patients with moderate elevations of low-density lipoprotein (LDL) cholesterol were randomly assigned to 4 different double-blind treatment regimens: placebo; colestipol 5 g and lovastatin 20 mg/day (C5 + L20); colestipol 10 g and lovastatin 20 mg/day (C10 + L20); and lovastatin 40 mg/...

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Bibliographic Details
Published in:The American journal of cardiology 1995, Vol.75 (1), p.34-39
Main Authors: Schrott, Helmut G., Stein, Evan A., Dujovne, Carlos A., Davidson, Michael H., Goris, George B., Oliphant, Thomas H., Phillips, Joann C., Shawaryn, Gregory G.
Format: Article
Language:English
Subjects:
Apolipoproteins - blood
Biological and medical sciences
Cholesterol
Cholesterol, LDL - blood
Colestipol - administration & dosage
Colestipol - therapeutic use
Cost-Benefit Analysis
Disorders of blood lipids. Hyperlipoproteinemia
Double-Blind Method
Drug therapy
Drug Therapy, Combination
Female
Humans
Hypercholesterolemia - blood
Hypercholesterolemia - drug therapy
Hypercholesterolemia - economics
Lipids - blood
Lipoproteins - blood
Lovastatin - administration & dosage
Lovastatin - therapeutic use
Male
Medical research
Medical sciences
Metabolic diseases
Middle Aged
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Summary:A total of 96 patients with moderate elevations of low-density lipoprotein (LDL) cholesterol were randomly assigned to 4 different double-blind treatment regimens: placebo; colestipol 5 g and lovastatin 20 mg/day (C5 + L20); colestipol 10 g and lovastatin 20 mg/day (C10 + L20); and lovastatin 40 mg/day (L40). During 12 weeks of therapy, C10 + L20 achieved the greatest reduction in total cholesterol (−32%) and LDL cholesterol (−48%) levels from baseline. This combination also exhibited significantly greater reductions in LDL cholesterol levels than the C5 + L20 and L40 groups (p
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(99)80523-2