Localization and Morphology of Antigen-Presenting Cells in the Adenoid of Children with Otitis Media with Effusion

This study describes the localization of antigen-presenting cells (APC) in the different compartments in adenoids of children with otitis media with effusion (OME) and "healthy" children and adults. It is shown that the adenoid of children with OME contains a relatively high number of OKT6...

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Bibliographic Details
Published in:Clinical immunology and immunopathology 1995-01, Vol.74 (1), p.59-69
Main Authors: van Nieuwkerk, E.B.J., van der Baan, S., Hoefsmit, E.C.M., Kamperdijk, E.W.A.
Format: Article
Language:English
Subjects:
Acid Phosphatase - analysis
Adenoids - immunology
Adenoids - pathology
Analysis of the immune response. Humoral and cellular immunity
Antibodies, Monoclonal
Antigen-Presenting Cells - cytology
B-Lymphocytes - cytology
B-Lymphocytes - immunology
Biological and medical sciences
Child
Child, Preschool
Dendritic Cells - cytology
Dendritic Cells - immunology
Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Histocytochemistry
Humans
Immunobiology
Immunohistochemistry
Infant
Male
Medical sciences
Microscopy, Electron
Miscellaneous
Non tumoral diseases
Otitis Media with Effusion - immunology
Otitis Media with Effusion - pathology
Otorhinolaryngology. Stomatology
Regulatory factors and their cellular receptors
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Summary:This study describes the localization of antigen-presenting cells (APC) in the different compartments in adenoids of children with otitis media with effusion (OME) and "healthy" children and adults. It is shown that the adenoid of children with OME contains a relatively high number of OKT6 and RFD1 positive cells. Moreover, accumulations of these cells are present in the extrafollicular areas of these adenoids. Very occasionally dendritic cells in the epithelial microenvironment contain Birbeck granules, indicating characteristic Langerhans cells. These OKT6 positive cells are not seen in the adenoids of the control group. Our results clearly show a relation between the presence of dendritic cells and the occurrence of OME. No differences are seen in localization and morphology of the APC in the studied adenoids.
ISSN:0090-1229
1090-2341
DOI:10.1006/clin.1995.1009