INFUSION OF VECURONIUM CONTROLLED BY A CLOSED-LOOP SYSTEM

Closed-loop control of neuromuscular blockade, using a semi-continuous infusion of vecuronium, is described. In 28 patients, the average neuromuscular transmission was between 13 and 17% of control. Requirements for vecuronium averaged 1.1 µg kg−1 min−1 (.8–1.5 fig kg−1 min−1). being in the same ran...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1986-10, Vol.58 (10), p.1100-1103
Main Authors: DE VRIES, J.W., BOOIJ, L.H.D.J., ROS, H.H.
Format: Article
Language:English
Subjects:
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
Feasibility Studies
Humans
Infusion Pumps
Infusions, Intravenous - instrumentation
Infusions, Intravenous - methods
Medical sciences
Muscle Contraction - drug effects
Neuropharmacology
Pharmacology. Drug treatments
Time Factors
Vecuronium Bromide - administration & dosage
Vecuronium Bromide - pharmacology
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Summary:Closed-loop control of neuromuscular blockade, using a semi-continuous infusion of vecuronium, is described. In 28 patients, the average neuromuscular transmission was between 13 and 17% of control. Requirements for vecuronium averaged 1.1 µg kg−1 min−1 (.8–1.5 fig kg−1 min−1). being in the same range as for repeated bolus injections. No side effects were observed. After the infusion was stopped recovery was rapid. Only three patients required induced reversal of blockade.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/58.10.1100