Effect of pharmacological stimulation and blockade of alpha-adrenergic receptors on adrenocorticotropic hormone and cortisol in the blood of people of various age

Age-associated peculiarities of the pituitary-adrenal system reactions to alpha 1-adrenergic preparations were studied in 60 normal adult, elderly and old subjects. Concentrations of ACTH and cortisol in blood were determined by the radioimmune method before and 2 hours after prazosin was given or 2...

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Bibliographic Details
Published in:Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Ukraine : 1994), 1994-03, Vol.40 (2), p.15-19
Main Authors: Shatylo, V B, Fedirko, M I
Format: Article
Language:Ukrainian
Subjects:
Adrenocorticotropic Hormone - blood
Adrenocorticotropic Hormone - drug effects
Adult
Age Factors
Aged
Aged, 80 and over
Humans
Hydrocortisone - blood
Male
Middle Aged
Phenylephrine - pharmacology
Pituitary-Adrenal System - drug effects
Pituitary-Adrenal System - metabolism
Prazosin - pharmacology
Receptors, Adrenergic, alpha - drug effects
Receptors, Adrenergic, alpha - metabolism
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Summary:Age-associated peculiarities of the pituitary-adrenal system reactions to alpha 1-adrenergic preparations were studied in 60 normal adult, elderly and old subjects. Concentrations of ACTH and cortisol in blood were determined by the radioimmune method before and 2 hours after prazosin was given or 20 and 60 min. after intake of phenylephrine hydrochloride. The activation of alpha 1-adrenergic receptors (phenylephrine) caused an increase in the blood concentrations of ACTH and cortisol, whereas the blockade of alpha 1-adrenergic receptors (prazosin) induced an essential decrease in the concentrations of these hormones in blood of the persons investigated at various age. In persons of higher-age groups phenylephrine caused a higher activation of the pituitary-adrenal system.
ISSN:2522-9028