Platelet Activity in Cluster Headache

Platelets are known to be activated in common or classic migraine both during the attack and in headache-free periods. Platelet behavior is less well known in cluster headache. We have investigated beta-thromboglobulin (b-TG) and platelet factor four (PF4) plasma levels, markers of in vivo platelet...

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Bibliographic Details
Published in:Cephalalgia 1986-09, Vol.6 (3), p.163-167
Main Authors: D'Andrea, Giovanni, Cananzi, Antonio R, Toldo, Moreno, Ferro-Milone, Francesco
Format: Article
Language:English
Subjects:
Adult
Aged
beta-Thromboglobulin - analysis
Beta‐thromboglobulin
Blood Platelets - metabolism
cluster headache
Cluster Headache - blood
Female
Humans
Male
Middle Aged
platelet activation
Platelet Factor 4 - analysis
platelet factor four
Vascular Headaches - blood
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Summary:Platelets are known to be activated in common or classic migraine both during the attack and in headache-free periods. Platelet behavior is less well known in cluster headache. We have investigated beta-thromboglobulin (b-TG) and platelet factor four (PF4) plasma levels, markers of in vivo platelet activation, in patients during remission and during bouts of cluster headache with and without pain. The results indicated that statistically significantly higher levels of b-TG and PF4 occur in the patients during the remission period when compared with the control subjects. Such high levels seemed to persist between paroxysmal episodes in cluster periods. However, during the attacks of cluster headache b-TG and PF4 plasma levels decreased by 42% and 50%, respectively, in comparison with plasma concentrations measured outside of attack. Thus, although platelet activation also occurs in patients with cluster headache, the attack as such seems to be characterized by a marked reduction in platelet activation.
ISSN:0333-1024
1468-2982
DOI:10.1046/j.1468-2982.1986.0603163.x