Formation of didesmethylethimizol (4-5-dicarbamoyl-1-ethylimidazole) in man

The chemical structure of an ethimizol metabolite found earlier in human urine and saliva was established as 4,5-dicarbamoyl-1-ethylimidazole (didesmethylethimizol). The treatment of biological samples comprised a solid-phase extraction, high-performance thin-layer chromatographic separation and hig...

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Bibliographic Details
Published in:European journal of drug metabolism and pharmacokinetics 1986-04, Vol.11 (2), p.87-89
Main Authors: PIOTROVSKY, L. B, ALEXANDROVA, I. YA, SOLTES, L, STEFEK, M, TRNOVEC, T
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chemical Phenomena
Chemistry
Chromatography, High Pressure Liquid
Etimizol - analogs & derivatives
Etimizol - isolation & purification
Etimizol - urine
Humans
Imidazoles
Mass Spectrometry
Medical sciences
Methylation
Miscellaneous
Neuropharmacology
Pharmacology. Drug treatments
Saliva - analysis
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Summary:The chemical structure of an ethimizol metabolite found earlier in human urine and saliva was established as 4,5-dicarbamoyl-1-ethylimidazole (didesmethylethimizol). The treatment of biological samples comprised a solid-phase extraction, high-performance thin-layer chromatographic separation and high-performance liquid chromatographic purification techniques. The identification of the metabolite was based on the comparison of a mass spectrum of the substance isolated from the biological fluid with the mass spectra of synthetised reference compounds.
ISSN:0378-7966
2107-0180
DOI:10.1007/BF03189832