Nimodipine in the Treatment of Headache in Chronic Cerebral Ischemia

The aim of this study was to evaluate the influence of nimodipine on non-migrainous vascular headache in patients with chronic cerebral ischemia. Eighty-six patients were examined in a double-blind trial for 16 weeks (12 weeks of nimodipine or placebo, followed by a 4-week placebo period). Fifty-six...

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Bibliographic Details
Published in:Cephalalgia 1986-09, Vol.6 (3), p.131-134
Main Authors: Hadjiev, Dimiter, Velcheva, Irena, Ivanova, Lilia
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Brain Ischemia - complications
Chronic cerebral ischemia
Chronic Disease
Clinical Trials as Topic
Double-Blind Method
Female
Humans
Male
Middle Aged
nimodipine
Nimodipine - therapeutic use
non‐migrainous vascular headache
Random Allocation
Vascular Headaches - drug therapy
Vascular Headaches - etiology
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Summary:The aim of this study was to evaluate the influence of nimodipine on non-migrainous vascular headache in patients with chronic cerebral ischemia. Eighty-six patients were examined in a double-blind trial for 16 weeks (12 weeks of nimodipine or placebo, followed by a 4-week placebo period). Fifty-six patients were studied in an open trial for 12 months. In the total material of the double-blind study there was no difference as far as improvement of headache was concerned when comparing the patients treated with nimodipine with those receiving placebo. However, in a group of 38 patients with a higher degree of headache intensity, selected in accordance with the Sandoz Clinical Assessment Geriatric scale, a statistically significant difference was found in favor of nimodipine. The results obtained in the long-term open trial seem to confirm the effect of nimodipine on headache. The underlying mechanisms of the beneficial effect of the drug have been discussed.
ISSN:0333-1024
1468-2982
DOI:10.1046/j.1468-2982.1986.0603131.x