[ 18F]Fluoro- l-dopa for the in vivo study of intracerebral dopamine

6-[ 18F]Fluoro- l-dopa was designed to trace the dopamine metabolism in the brain with positron tomography. 6-[ 18F]Fluoro- l-dopa resembles natural l-dopa biochemically, it crosses the blood-brain barrier with the similar kinetics, it is decarboxylated by dopa decarboxylase and is stored intraneuro...

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Bibliographic Details
Published in:International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes Applied radiation and isotopes, 1986, Vol.37 (8), p.669-675
Main Authors: Firnau, Gunter, Garnett, E.S., Chirakal, Raman, Sood, Sudesh, Nahmias, Claude, Schrobilgen, Gary
Format: Article
Language:English
Subjects:
Animals
Brain - diagnostic imaging
Brain - metabolism
Dihydroxyphenylalanine - analogs & derivatives
Dihydroxyphenylalanine - chemical synthesis
Dihydroxyphenylalanine - metabolism
Dopamine - metabolism
Humans
Methylation
Radiochemistry
Radioisotopes
Safety
Tomography, Emission-Computed
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Summary:6-[ 18F]Fluoro- l-dopa was designed to trace the dopamine metabolism in the brain with positron tomography. 6-[ 18F]Fluoro- l-dopa resembles natural l-dopa biochemically, it crosses the blood-brain barrier with the similar kinetics, it is decarboxylated by dopa decarboxylase and is stored intraneuronally in vesicles. In addition the rate of O-methylation of 6-[ 18F]fluoro- l-dopa by catechol-O-methyl transferase is only 1 4 of that of natural l-dopa. The low rate of O-methylation, especially in the periphery, is particularly beneficial for PT investigations of the brain. The radiotracer has been synthesized using a variety of electrophilic fluorinating agents.
ISSN:0883-2889
DOI:10.1016/0883-2889(86)90260-1