Aqueous penetration of orally administered ciprofloxacin in humans

The aqueous penetration of orally administered Ciprofloxacin (CPX) was studied in twenty-two human volunteers undergoing cataract surgery. CPX in a dose of 250 mg, was given p.o. at 12 hourly intervals in 3 groups such that a maximum dose of 0.5 grams was delivered in one group, 1.0 grams in another...

Full description

Saved in:
Bibliographic Details
Published in:International ophthalmology 1994-01, Vol.18 (4), p.221-224
Main Authors: Gulati, V K, Desai, S, Khatri, P K, Joshi, K R
Format: Article
Language:English
Subjects:
Administration, Oral
Aged
Aged, 80 and over
Aqueous Humor - metabolism
Biological Availability
Cataract Extraction
Ciprofloxacin - administration & dosage
Ciprofloxacin - pharmacokinetics
Female
Humans
Male
Middle Aged
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aqueous penetration of orally administered Ciprofloxacin (CPX) was studied in twenty-two human volunteers undergoing cataract surgery. CPX in a dose of 250 mg, was given p.o. at 12 hourly intervals in 3 groups such that a maximum dose of 0.5 grams was delivered in one group, 1.0 grams in another and 1.5 grams in the last group. A fourth group consisted of 6 individuals who were controls and received lactose tablets. Twelve hours after the last dosing aqueous samples were collected and assayed by the Grove-Randall technique. The aqueous penetration of Ciprofloxacin achieved was 1.51 +/- 0.15 mgL-1 in group II and 2.49 +/- 0.52 mgL-1 in group III. In group I, the aqueous concentration was experimentally indeterminate and the control samples in group IV did not show any antibacterial activity. Divided oral doses of 1.5 grams of CPX were found to produce an aqueous titre up to 2.5 times the MIC of Ps. aeruginosa.
ISSN:0165-5701
1573-2630
DOI:10.1007/BF00951801