The role of renal prostaglandin E as a possible modulator of cyclic AMP production in nephrotic syndrome

Urinary prostaglandin E (PGE) and cyclic AMP (cAMP) excretions were studied by radioimmunoassay in children with nephrotic syndrome and in a control population. In cases with nephrotic syndrome there was a significant elevation in urinary PGE excretion and cAMP excretion was decreased. A positive co...

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Bibliographic Details
Published in:International urology and nephrology 1986-09, Vol.18 (3), p.321-325
Main Authors: Túri, S, Havass, Z, Bodrogi, T
Format: Article
Language:English
Subjects:
Adolescent
Blood
Child
Child, Preschool
Cyclic AMP - urine
Humans
Nephrotic Syndrome - urine
Osmolar Concentration
Prostaglandins E - urine
Urine
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Summary:Urinary prostaglandin E (PGE) and cyclic AMP (cAMP) excretions were studied by radioimmunoassay in children with nephrotic syndrome and in a control population. In cases with nephrotic syndrome there was a significant elevation in urinary PGE excretion and cAMP excretion was decreased. A positive correlation was found between urinary cAMP excretion and urinary osmolality (Uosm) and the ratio urine to plasma osmolality (Uosm/Posm); and a negative correlation between urinary cAMP excretion and urine volume. A negative correlation was observed between the values of PGE excretion and urinary cAMP. These data confirmed the role of PGE as a modulator of cAMP production, which was inhibited in the nephrotic syndrome.
ISSN:0301-1623
1573-2584
DOI:10.1007/BF02082721