Comparison of pharmacokinetics and bactericidal activity of teicoplanin and vancomycin

Teicoplanin (0.2 g) or vancomycin (1 g) were infused over 3 and 50 min respectively to six male volunteers in a cross-over study. Each drug was administered twice at a 14 h interval. The pharmacokinetics of both drugs were accurately described using a two-compartment model. Vancomycin had a shorter...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1986-10, Vol.18 (4), p.513-520
Main Authors: Lagast, H., Dodion, P., Klastersky, J.
Format: Article
Language:English
Subjects:
Adult
Enterococcus faecalis - drug effects
Glycopeptides - blood
Glycopeptides - pharmacology
Glycopeptides - urine
Humans
Kinetics
Male
Microbial Sensitivity Tests
Staphylococcus aureus - drug effects
Staphylococcus epidermidis - drug effects
Teicoplanin
Vancomycin - blood
Vancomycin - pharmacology
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Summary:Teicoplanin (0.2 g) or vancomycin (1 g) were infused over 3 and 50 min respectively to six male volunteers in a cross-over study. Each drug was administered twice at a 14 h interval. The pharmacokinetics of both drugs were accurately described using a two-compartment model. Vancomycin had a shorter half-life (5.8±1.8 h) compared to teicoplainin (33.2±5.1h; P
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/18.4.513