Proximity versus allostery: the role of regulated protein dimerization in biology

Regulated dimerization of proteins is increasingly understood to be important in many cellular processes, including signaling, transcription and protein degradation. Organic molecules that induce dimerization may offer as much potential to regulate biological processes as those that allosterically i...

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Bibliographic Details
Published in:Chemistry & biology 1994-11, Vol.1 (3), p.131-136
Main Authors: Austin, David J., Schreiber, Stuart L., Crabtree, Gerald R.
Format: Article
Language:English
Subjects:
Animals
Dimerization
Humans
Protein Conformation
Proteins - chemistry
Proteins - metabolism
Proteins - physiology
Signal Transduction - physiology
Transcription, Genetic - physiology
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Summary:Regulated dimerization of proteins is increasingly understood to be important in many cellular processes, including signaling, transcription and protein degradation. Organic molecules that induce dimerization may offer as much potential to regulate biological processes as those that allosterically induce conformational change.
ISSN:1074-5521
1879-1301
DOI:10.1016/1074-5521(94)90002-7