Relation of angiographically defined coronary artery disease and plasma concentrations of insulin, lipid, and apolipoprotein in normolipidemic subjects with varying degrees of glucose tolerance

• Published in: The American journal of cardiology 1995-01, Vol.75 (2), p.122-126
• Main Authors: Fujiwara, Ryuichi, Kutsumi, Yasunori, Hayashi, Takio, Nishio, Hiroyuki, Koshino, Yusuke, Shimada, Yoshifumi, Nakai, Tsuguhiko, Miyabo, Susumu
• Format: Article
• Language: English
• Subjects: Apolipoprotein A-I - blood; Apolipoproteins B - blood; Biological and medical sciences; Blood Glucose - metabolism; Cardiology. Vascular system; Cardiovascular disease; Coronary Angiography; Coronary Disease - blood; Coronary Disease - complications; Coronary Disease - diagnostic imaging; Coronary heart disease; Coronary vessels; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Glucose Intolerance - blood; Glucose Intolerance - complications; Glucose Tolerance Test; Heart; Humans; Insulin - blood; Lipids; Lipids - blood; Male; Medical research; Medical sciences; Metabolism; Middle Aged; Proteins; Regression Analysis; Risk Factors
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/S0002-9149(00)80059-4

We investigated the association between hyperinsulinemia ana changes in lipid, lipoprotein, and apolipoprotein that would increase the risk of coronary artery disease (CAD) independent of glucose tolerance. A coronary angiogram was recorded in 127 male subjects, including 41 with normal glucose tolerance, 41 with impaired glucose tolerance, and 45 with non-insulin-dependent diabetes mellitus (NIDDM). Subjects were divided info 2 groups according to results: the group with CAD (n = 94) and the group with normal coronary arteries (n = 33). All subjects were normolipidemic (total cholesterol