Enhanced Serological and Virological Findings of Epstein-Barr Virus in Patients with AIDS and AIDS-Related Complex

The potential involvement of Epstein-Barr virus (EBV) in AIDS was examined by determining the type of EBV-specific antibody responses and the EBV content or lymphoproliferative ability present in selected body fluids of patients with AIDS or AIDS-related complex. The results were compared with two c...

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Bibliographic Details
Published in:The Journal of infectious diseases 1986-11, Vol.154 (5), p.864-870
Main Authors: Sumaya, Ciro Valent, Boswell, Richard Neal, Ench, Yasmin, Kisner, Daniel L., Hersh, Evan M., Reuben, James M., Mansell, Peter W. A.
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - microbiology
AIDS
AIDS related complex
AIDS-Related Complex - microbiology
AIDS/HIV
Antibodies
Antibodies, Viral - analysis
Antigens
Biological and medical sciences
Blood
Body Fluids - analysis
Capsid
Epstein Barr virus infections
Herpesvirus 4, Human - immunology
Herpesvirus 4, Human - isolation & purification
Human herpesvirus 4
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulin A - analysis
Immunoglobulin G - analysis
Immunoglobulin M - analysis
Immunopathology
Infectious mononucleosis
Medical sciences
Original Articles
Prospective Studies
Viruses
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Summary:The potential involvement of Epstein-Barr virus (EBV) in AIDS was examined by determining the type of EBV-specific antibody responses and the EBV content or lymphoproliferative ability present in selected body fluids of patients with AIDS or AIDS-related complex. The results were compared with two control groups. An enhanced antibody response to a broad spectrum of EBV antigens was found in patients with AIDS or AIDS-related complex. The pattern of virus-specific antibody responses resembled that associated with a persistent or reactivated infection. The content of EBV in oropharyngeal secretions and the lymphoproliferative ability in peripheral blood from patients with AIDS or AIDSrelated complex was significantly greater than that from healthy controls and approached levels detected in the control group with infectious mononucleosis. These findings, together with recent reports of cellular-level interaction between EBV and human T lymphotropic virus type III, suggest that EBV may have a contributory role in these disorders.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/154.5.864