Vaccinated Children Get Milder Measles Infection: A Community Study from Guinea-Bissau

We studied the occurrence of measles in vaccinated children from an urban area of GuineaBissau where measles causes high mortality. Vaccinated children who developed measles required more-intense exposure to become infected (they had a higher ratio of secondary cases [infected in the house] to index...

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Bibliographic Details
Published in:The Journal of infectious diseases 1986-11, Vol.154 (5), p.858-863
Main Authors: Aaby, Peter, Bukh, Jette, Leerhøy, Jørgen, Lisse, Ida Maria, Mordhorst, Carl H., Pedersen, Ib Rode
Format: Article
Language:English
Subjects:
Age Factors
Antibodies
Antibodies, Viral - analysis
Biological and medical sciences
Child
Child development
Child nutrition
Child, Preschool
Children
Epidemiologic Methods
Epidemiology
Guinea-Bissau
Human viral diseases
Humans
Immunization
Infant
Infections
Infectious diseases
Measles
Measles - epidemiology
Measles - mortality
Measles - prevention & control
Measles Vaccine - therapeutic use
Measles virus - immunology
Medical sciences
Mortality
Original Articles
Vaccination
Viral diseases
Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
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Summary:We studied the occurrence of measles in vaccinated children from an urban area of GuineaBissau where measles causes high mortality. Vaccinated children who developed measles required more-intense exposure to become infected (they had a higher ratio of secondary cases [infected in the house] to index cases [infected outside the house]), had a lower mortality among secondary cases, and were less infectious (they generated fewer secondary cases than did unvaccinated children with measles). The attack rate among vaccinated children was significantly higher in households in which someone died of measles. Both severity of infection and development of measles in vaccinated children were related to intensity of exposure. Vaccine efficacy was 72%, and 33% of cases occurred among vaccinated children; however, most mothers remained confident that vaccinated children get milder measles. Moreover, there was significantly greater vaccination coverage among younger siblings of vaccinated children who had contracted measles than among other children in the community.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/154.5.858