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Intact survival with transfusion-associated graft-versus-host disease proved by human leukocyte antigen typing of lymphocytes in skin biopsy specimens

A transient transfusion-associated graft-versus-host disease occurred in a premature infant of 30 weeks of gestation. We demonstrated donor lymphocytes in a skin biopsy specimen with a two-step immunoperoxidase technique using monoclonal antibodies against human leukocyte antigen determinants specif...

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Bibliographic Details
Published in:The Journal of pediatrics 1995, Vol.126 (1), p.61-64
Main Authors: Hentschel, R., Broecker, E.B., Kolde, G., Frosch, M., Friedrich, W., Holzgreve, W., Westphal, E., Harms, E.
Format: Article
Language:English
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Summary:A transient transfusion-associated graft-versus-host disease occurred in a premature infant of 30 weeks of gestation. We demonstrated donor lymphocytes in a skin biopsy specimen with a two-step immunoperoxidase technique using monoclonal antibodies against human leukocyte antigen determinants specific for the donor. The girl survived and is immunocompetent. (J P EDIATR 1995;126: 61-4)
ISSN:0022-3476
1097-6833
DOI:10.1016/S0022-3476(95)70503-1