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Tetracaine, Epinephrine (Adrenalin), and Cocaine (TAC) Versus Lidocaine, Epinephrine, and Tetracaine (LET) for Anesthesia of Lacerations in Children

Study objective: To compare the duration of anesthesia experienced with lidocaine, epinephrine, and tetracaine (LET) solution and that with tetracaine, epinephrine (Adrenalin), and cocaine (TAC) solution during suturing of uncomplicated lacerations on the face or scalp. Design: Double-blind, randomi...

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Published in:Annals of emergency medicine 1995-02, Vol.25 (2), p.203-208
Main Authors: Schilling, Craig G, Bank, David E, Borchert, Barbara A, Klatzko, Martin D, Uden, Donald L
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container_title Annals of emergency medicine
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creator Schilling, Craig G
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description Study objective: To compare the duration of anesthesia experienced with lidocaine, epinephrine, and tetracaine (LET) solution and that with tetracaine, epinephrine (Adrenalin), and cocaine (TAC) solution during suturing of uncomplicated lacerations on the face or scalp. Design: Double-blind, randomized, controlled trial. Setting: The emergency department of a university-affiliated private children's hospital. Participants: One hundred seventy-one children with lacerations on the face and scalp requiring suturing. Interventions: After standard application of the anesthetic solution, patients were assessed for signs of discomfort before and during laceration repair. Duration of anesthesia during laceration repair was determined on the basis of the length of time after removal of the anesthetic solution to the first sign(s) of discomfort that required additional anesthesia. Results: There was no statistical difference between TAC and LET in adequacy of anesthesia before suturing or in duration of anesthesia during suturing. Conclusion: LET is an effective alternative to TAC for topical anesthesia during suturing of uncomplicated lacerations on the face and scalp in children. [Schilling CG, Bank DE, Borchert BA, Klatzko MD, Uden DL: Tetracaine, epinephrine (Adrenalin), and cocaine (TAC) versus lidocaine, epinephrine, and tetracaine (LET) for anesthesia of lacerations in children. Ann Emerg Med February 1995;25:203-208.]
doi_str_mv 10.1016/S0196-0644(95)70325-X
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Design: Double-blind, randomized, controlled trial. Setting: The emergency department of a university-affiliated private children's hospital. Participants: One hundred seventy-one children with lacerations on the face and scalp requiring suturing. Interventions: After standard application of the anesthetic solution, patients were assessed for signs of discomfort before and during laceration repair. Duration of anesthesia during laceration repair was determined on the basis of the length of time after removal of the anesthetic solution to the first sign(s) of discomfort that required additional anesthesia. Results: There was no statistical difference between TAC and LET in adequacy of anesthesia before suturing or in duration of anesthesia during suturing. Conclusion: LET is an effective alternative to TAC for topical anesthesia during suturing of uncomplicated lacerations on the face and scalp in children. [Schilling CG, Bank DE, Borchert BA, Klatzko MD, Uden DL: Tetracaine, epinephrine (Adrenalin), and cocaine (TAC) versus lidocaine, epinephrine, and tetracaine (LET) for anesthesia of lacerations in children. Ann Emerg Med February 1995;25:203-208.]</description><identifier>ISSN: 0196-0644</identifier><identifier>EISSN: 1097-6760</identifier><identifier>DOI: 10.1016/S0196-0644(95)70325-X</identifier><identifier>PMID: 7832348</identifier><identifier>CODEN: AEMED3</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adolescent ; Anesthesia, Local ; Anesthetics. Neuromuscular blocking agents ; Biological and medical sciences ; Child ; Child, Preschool ; Cocaine - therapeutic use ; Double-Blind Method ; Drug Combinations ; Epinephrine - therapeutic use ; Female ; Humans ; Infant ; Lidocaine - therapeutic use ; Male ; Medical sciences ; Neuropharmacology ; Pain - etiology ; Pain - prevention &amp; control ; Pharmacology. 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Design: Double-blind, randomized, controlled trial. Setting: The emergency department of a university-affiliated private children's hospital. Participants: One hundred seventy-one children with lacerations on the face and scalp requiring suturing. Interventions: After standard application of the anesthetic solution, patients were assessed for signs of discomfort before and during laceration repair. Duration of anesthesia during laceration repair was determined on the basis of the length of time after removal of the anesthetic solution to the first sign(s) of discomfort that required additional anesthesia. Results: There was no statistical difference between TAC and LET in adequacy of anesthesia before suturing or in duration of anesthesia during suturing. Conclusion: LET is an effective alternative to TAC for topical anesthesia during suturing of uncomplicated lacerations on the face and scalp in children. [Schilling CG, Bank DE, Borchert BA, Klatzko MD, Uden DL: Tetracaine, epinephrine (Adrenalin), and cocaine (TAC) versus lidocaine, epinephrine, and tetracaine (LET) for anesthesia of lacerations in children. Ann Emerg Med February 1995;25:203-208.]</description><subject>Adolescent</subject><subject>Anesthesia, Local</subject><subject>Anesthetics. Neuromuscular blocking agents</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cocaine - therapeutic use</subject><subject>Double-Blind Method</subject><subject>Drug Combinations</subject><subject>Epinephrine - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Lidocaine - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pain - etiology</subject><subject>Pain - prevention &amp; control</subject><subject>Pharmacology. 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Neuromuscular blocking agents</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cocaine - therapeutic use</topic><topic>Double-Blind Method</topic><topic>Drug Combinations</topic><topic>Epinephrine - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Lidocaine - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Pain - etiology</topic><topic>Pain - prevention &amp; control</topic><topic>Pharmacology. 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Design: Double-blind, randomized, controlled trial. Setting: The emergency department of a university-affiliated private children's hospital. Participants: One hundred seventy-one children with lacerations on the face and scalp requiring suturing. Interventions: After standard application of the anesthetic solution, patients were assessed for signs of discomfort before and during laceration repair. Duration of anesthesia during laceration repair was determined on the basis of the length of time after removal of the anesthetic solution to the first sign(s) of discomfort that required additional anesthesia. Results: There was no statistical difference between TAC and LET in adequacy of anesthesia before suturing or in duration of anesthesia during suturing. Conclusion: LET is an effective alternative to TAC for topical anesthesia during suturing of uncomplicated lacerations on the face and scalp in children. 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subjects Adolescent
Anesthesia, Local
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
Child
Child, Preschool
Cocaine - therapeutic use
Double-Blind Method
Drug Combinations
Epinephrine - therapeutic use
Female
Humans
Infant
Lidocaine - therapeutic use
Male
Medical sciences
Neuropharmacology
Pain - etiology
Pain - prevention & control
Pharmacology. Drug treatments
Skin - injuries
Solutions
Sutures
Tetracaine - therapeutic use
Wounds and Injuries - therapy
title Tetracaine, Epinephrine (Adrenalin), and Cocaine (TAC) Versus Lidocaine, Epinephrine, and Tetracaine (LET) for Anesthesia of Lacerations in Children
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