Haemoglobin-based blood substitutes and sepsis

An important concern that has received little attention is the possible increased susceptibility to bacterial infections of patients infused with cell-free haemoglobin-based blood substitutes. We show that pyridoxalated polymerised human haemoglobin promotes fulminating Escherichia colisepticaemia i...

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Bibliographic Details
Published in:The Lancet (British edition) 1995-01, Vol.345 (8943), p.158-160
Main Authors: Griffiths, Elwyn, Cortes, Angeles, Gilbert, Nicholas, Stevenson, Pauline, MacDonald, Shirley, Pepper, Duncan
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Bacterial diseases
Biological and medical sciences
Blood
Blood Substitutes - pharmacology
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
Disease Susceptibility
E coli
Escherichia coli - pathogenicity
Escherichia coli Infections - microbiology
Hemoglobin
Hemoglobins - pharmacology
Medical research
Medical sciences
Mice
Pyridoxal Phosphate - analogs & derivatives
Pyridoxal Phosphate - pharmacology
Rodents
Sepsis - microbiology
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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Summary:An important concern that has received little attention is the possible increased susceptibility to bacterial infections of patients infused with cell-free haemoglobin-based blood substitutes. We show that pyridoxalated polymerised human haemoglobin promotes fulminating Escherichia colisepticaemia in mice, which draws attention to the potential danger of such products in the clinic.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(95)90168-X