Sex Differences in Regional Cerebral Glucose Metabolism During a Resting State

Positron emission tomography was used to evaluate the regional distribution of cerebral glucose metabolism in 61 healthy adults at rest. Although the profile of metabolic activity was similar for men and women, some sex differences and hemispheric asymmetries were detectable. Men had relatively high...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1995-01, Vol.267 (5197), p.528-531
Main Authors: Gur, Ruben C., Mozley, Lyn Harper, Mozley, P. David, Resnick, Susan M., Karp, Joel S., Alavi, Abass, Arnold, Steven E., Gur, Raquel E.
Format: Article
Language:English
Subjects:
Adult
Basal ganglia
Basal Ganglia - metabolism
Basal metabolism
Biochemistry and metabolism
Biological and medical sciences
Brain
Brain - diagnostic imaging
Brain - metabolism
Brain Hemisphere Functions
Brain Stem - metabolism
Central nervous system
Cerebellum
Cerebellum - metabolism
Corpus callosum
Discrimination Learning
Female
Females
Functional Laterality
Fundamental and applied biological sciences. Psychology
Gender Differences
Gender Discrimination
Glucose - metabolism
Gyrus Cinguli - metabolism
Humans
Individual Differences
Interrater Reliability
Limbic System - metabolism
Male
Males
Men
Metabolism
Motor ability
Neuropsychology
Occipital Lobe - metabolism
Positron emission tomography
Sex Characteristics
Sex linked differences
Sexes
Specialization
Statistical Analysis
Temporal Lobe - metabolism
Tomography, Emission-Computed
Topography
Vertebrates: nervous system and sense organs
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Summary:Positron emission tomography was used to evaluate the regional distribution of cerebral glucose metabolism in 61 healthy adults at rest. Although the profile of metabolic activity was similar for men and women, some sex differences and hemispheric asymmetries were detectable. Men had relatively higher metabolism than women in temporal-limbic regions and cerebellum and relatively lower metabolism in cingulate regions. In both sexes, metabolism was relatively higher in left association cortices and the cingulate region and in right ventro-temporal limbic regions and their projections. These results are consistent with the hypothesis that differences in cognitive and emotional processing have biological substrates.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7824953