Improvement of cardiac performance by carboxylic ionophore monensin in greyhound and mongrel dogs

The effects of the cardiotonic ionophore monensin on coronary blood flow, cardiac output, left ventricular (LV) O2 consumption, LV contractility and arterial blood pressure were measured in greyhounds and compared with those in mongrel dogs under pentobarbital anaesthesia. Following intravenous inje...

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Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology 1986-08, Vol.333 (4), p.412-420
Main Authors: MOHAMMAD FAHIM, PRESSMAN, B. C
Format: Article
Language:English
Subjects:
Animals
Applied sciences
Biological and medical sciences
Cardiotonic Agents
Cardiovascular system
Catecholamines - blood
Coronary Circulation - drug effects
Dogs
Exact sciences and technology
Heart - drug effects
Medical sciences
Monensin - pharmacology
Myocardium - metabolism
Organ Size - drug effects
Other techniques and industries
Oxygen Consumption - drug effects
Pharmacology. Drug treatments
Species Specificity
Vascular Resistance - drug effects
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Summary:The effects of the cardiotonic ionophore monensin on coronary blood flow, cardiac output, left ventricular (LV) O2 consumption, LV contractility and arterial blood pressure were measured in greyhounds and compared with those in mongrel dogs under pentobarbital anaesthesia. Following intravenous injection of 100 micrograms/kg monensin, all parameters rose, the greyhounds showing a relatively greater response in peak values of coronary blood flow, LV contractility and cardiac output. The increase in the calculated LV mechanical work was proportionately greater than the corresponding increase in LV O2 consumption, hence the derived index, external mechanical efficiency, rose rapidly from an initial value of 0.165 to 0.285 (73%) in greyhounds; mongrel dogs showed a more modest rise from 0.094 to 0.120 (28%) during the same interval. The difference in the responses in the two breeds of dogs are attributed mainly to larger heart size and exercise training in greyhounds as compared with untrained mongrel dogs.
ISSN:0028-1298
1432-1912
DOI:10.1007/BF00500018