Curcacycline A — a novel cyclic octapeptide isolated from the latex of Jatropha curcas L

From the latex of Jatropha curcas L. (Euphorbiaceae) a novel cyclic octapeptide was isolated, which we named curcacycline A. The compound was found to contain one threonine, one valine, two glycine, and four leucine residues. By two-dimensional 1H-NMR spectroscopy (HOHAHA and ROESY), its sequence wa...

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Bibliographic Details
Published in:FEBS letters 1995-01, Vol.358 (3), p.215-218
Main Authors: van den Berg, A.J.J., Horsten, S.F.A.J., Kettenes-van den Bosch, J.J., Kroes, B.H., Beukelman, C.J., Leeflang, B.R., Labadie, R.P.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Cell Division - drug effects
Complement Pathway, Classical - drug effects
Curcacycline A
Cyclic peptide
Euphorbiaceae
Humans
Jatropha curcas
Latex - chemistry
Magnetic Resonance Spectroscopy
Mass Spectrometry
Molecular Sequence Data
Peptides, Cyclic - chemistry
Peptides, Cyclic - isolation & purification
Peptides, Cyclic - pharmacology
Plant Proteins - chemistry
Plant Proteins - isolation & purification
Plant Proteins - pharmacology
Plants, Medicinal - chemistry
T-Lymphocytes - cytology
T-Lymphocytes - drug effects
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Summary:From the latex of Jatropha curcas L. (Euphorbiaceae) a novel cyclic octapeptide was isolated, which we named curcacycline A. The compound was found to contain one threonine, one valine, two glycine, and four leucine residues. By two-dimensional 1H-NMR spectroscopy (HOHAHA and ROESY), its sequence was determined to be Gly 1-Leu 2-Leu 3-Gly 4-Thr 5-Val 6-Leu 7Leu 8-Gly 1. Curcacycline A displays a moderate inhibition of (i) classical pathway activity of human complement and (ii) proliferation of human T-cells.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(94)01405-P