Detection of (11; 22)(q24;q12) Translocation-Bearing Cells in Peripheral Blood Progenitor Cells of Patients With Ewing's Sarcoma Family of Tumors

A study evaluated whether t(11;22)-positive cells could be detected in peripheral blood progenitor cell collections of Ewing's sarcoma patients and, if so, whether they would disappear with treatment. Results demonstrate that a reverse transcriptive-polymerase chain reaction assay can detect th...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1995-03, Vol.87 (5), p.385-386
Main Authors: Toretsky, Jeffrey A., Neckers, Leonard, Wexler, Leonard H.
Format: Article
Language:English
Subjects:
Base Sequence
Biochemistry
Biological and medical sciences
Bone Neoplasms - genetics
Cancer
Cellular biology
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 22
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical research
Medical sciences
Molecular Sequence Data
Neoplastic Stem Cells
Osteoarticular system. Muscles
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Polymerase Chain Reaction
Protein Biosynthesis
RNA, Neoplasm
Sarcoma, Ewing - genetics
Translocation, Genetic
Tumors
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Summary:A study evaluated whether t(11;22)-positive cells could be detected in peripheral blood progenitor cell collections of Ewing's sarcoma patients and, if so, whether they would disappear with treatment. Results demonstrate that a reverse transcriptive-polymerase chain reaction assay can detect the presence of t(11;22)-positive tumor cells in peripheral blood progenitor cell collections.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/87.5.385