Mechanisms of sepsis in acute pancreatitis in opossums

• Published in: The American journal of surgery 1995-02, Vol.169 (2), p.227-232
• Main Authors: Runkel, Norbert S.F., Rodriguez, Liliana F., Moody, Frank G.
• Format: Article
• Language: English
• Subjects: Acute Disease; Animals; Bacteremia; Bacteremia - microbiology; Bacteria; Bacteria - growth & development; Bile; Bile - microbiology; Biliary tract; Biliary Tract - microbiology; Biological and medical sciences; Colonization; Extravasation; Gastroenterology. Liver. Pancreas. Abdomen; Intestine; Liver; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Lymph nodes; Lymph Nodes - microbiology; Lymphatic system; Medical sciences; Microorganisms; Necrosis; Opossums; Other diseases. Semiology; Pancreas; Pancreatitis; Pancreatitis - microbiology; Pancreatitis - pathology; Salmonella - growth & development; Salmonella - isolation & purification; Sepsis; Spleen; Translocation
• ISSN: 0002-9610; 1879-1883
• DOI: 10.1016/S0002-9610(99)80142-1

To study the incidence and pathways of colonization of the pancreas by specific bacteria in a model of necrotizing pancreatitis. Bacteremia and splanchnic organ colonization were studied in the early course of necrotizing pancreatitis following common biliopancreatic duct ligation (BPDL) of the opossum. Nonoperated animals served as controls. Intestinal lymph nodes, liver, spleen, and pancreas were cultured following bacteremia or sacrifice. In opossums with sterile bile, bacteria were recovered from 28.6% of blood cultures after BPDL (n = 10) and from 12.0% in controls (n = 10, P