Gastroprotective effect of essential oil from Croton cajucara Benth. (Euphorbiaceae)

The gastroprotective activity of the essential oil from the bark of Croton cajucara Benth (Euphorbiaceae) was assessed in three different models of experimentally induced gastric ulcer in mice. At oral dose of 100 mg/kg the essential oil reduced gastric lesions induced by hypothermic restraint stres...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2000-03, Vol.69 (3), p.229-234
Main Authors: Hiruma-Lima, C.A, Gracioso, J.S, Rodrı́guez, J.A, Haun, M, Nunes, D.S, Souza Brito, A.R.M
Format: Article
Language:English
Subjects:
Animals
Antiulcerogenic activity
bark
Biological and medical sciences
Cell Line
Cell Survival - drug effects
Cricetinae
Croton cajucara
Essential oil
Euphorbiaceae
Euphorbiaceae - chemistry
General pharmacology
In vivo and in vitro toxicity
Lethal Dose 50
Medical sciences
medicinal plants
Mice
Oils, Volatile - pharmacology
Oils, Volatile - therapeutic use
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
sacaca
Stomach - drug effects
Stomach Ulcer - drug therapy
stomach ulcers
traditional medicine
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Summary:The gastroprotective activity of the essential oil from the bark of Croton cajucara Benth (Euphorbiaceae) was assessed in three different models of experimentally induced gastric ulcer in mice. At oral dose of 100 mg/kg the essential oil reduced gastric lesions induced by hypothermic restraint stress and HCl/ethanol significantly. In the HCl/ethanol model a dose-dependent gastroprotective effect was found. Moreover, significant changes in gastric parameters such as pH, secretion rate and total gastric acid were found after intraduodenal administration of essential oil under ligated pylorus (Shay) conditions. The acute toxicity of essential oil was assessed in mice. The LD 50 values were 9.3 and 680 mg/kg for oral and intraperitoneal administrations, respectively. The cytotoxicity of essential oil was studied also. A dose-dependent cell viability inhibition was found in V79 fibroblast cell cultures with an IC 50 of 22.9 μg/ml. Our results support the pharmacological study of this essential oil.
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(99)00127-0