Lactate Transporter Defect: A New Disease of Muscle

New methods were used to identify the abnormality in a patient who showed evidence of neuromuscular dysfunction on extensive clinical examination. The methods revealed that the lactate content of the patient's skeletal muscle does not decline normally after exercise and that his red cells are d...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1986-12, Vol.234 (4781), p.1254-1256
Main Author: Fishbein, William N.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood plasma
Carrier Proteins - metabolism
Cell membranes
Creatine Kinase - blood
Erythrocyte Membrane - metabolism
Erythrocytes
Erythrocytes - analysis
Fish
Glycolysis
Humans
Lactates
Lactates - blood
Lactates - metabolism
lactic acid
Male
man
Medical disorders
Medical sciences
Metabolic diseases
Miscellaneous
Monocarboxylic Acid Transporters
Muscle tissues
Muscles
Muscular diseases
Muscular Diseases - metabolism
Muscular system
Nervous system
Other metabolic disorders
Physical Exertion
Red blood cells
Skeletal muscle
Survival rates
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Summary:New methods were used to identify the abnormality in a patient who showed evidence of neuromuscular dysfunction on extensive clinical examination. The methods revealed that the lactate content of the patient's skeletal muscle does not decline normally after exercise and that his red cells are defective in lactate transport. These results suggest that skeletal muscle and erythrocyte membranes share the same genetic lactate transporter (or a common subunit), which is deficient in this patient. This defect may be a common cause of elevated serum creatine kinase levels, as seen in the patient described here and of unexplained episodes of rhabdomyolysis and myoglobinuria.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.3775384