Motor Sequencing Deficits in Schizophrenia: A Comparison With Parkinson's Disease

Motor abnormalities occur in schizophrenia (SZ) and may arise from striatal dysfunction. This study examined whether the pattern of performance on simple and complex motor abilities in SZ was similar to that of patients with Parkinson's disease (PD). Quantitative tests of speeded movement and m...

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Bibliographic Details
Published in:Neuropsychology 2001-07, Vol.15 (3), p.342-350
Main Authors: Sullivan, Edith V, Fama, Rosemary, Shear, Paula K, Cahn-Weiner, Deborah A, Stein, Maria, Zipursky, Robert B, Pfefferbaum, Adolf
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Aged
Biological and medical sciences
Cholinergic Antagonists - therapeutic use
Cognition Disorders - epidemiology
Cognition Disorders - etiology
Cognitive Processes
Corpus Striatum - physiopathology
Frontal Lobe - physiopathology
Human
Humans
Male
Medical sciences
Middle Aged
Motor Performance
Parkinson Disease - complications
Parkinson Disease - physiopathology
Parkinson's Disease
Psychology. Psychoanalysis. Psychiatry
Psychomotor Disorders - diagnosis
Psychomotor Disorders - epidemiology
Psychomotor Disorders - etiology
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - complications
Schizophrenia - drug therapy
Schizophrenia - physiopathology
Severity of Illness Index
Wechsler Scales
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Summary:Motor abnormalities occur in schizophrenia (SZ) and may arise from striatal dysfunction. This study examined whether the pattern of performance on simple and complex motor abilities in SZ was similar to that of patients with Parkinson's disease (PD). Quantitative tests of speeded movement and motor and cognitive sequencing were used to assess 25 SZ, 16 PD, and 84 normal controls (NCs). Sequencing performance was also examined with motor rigidity taken into account. Compared with the NC group, the SZ and PD groups were impaired on measures of motor rigidity and motor sequencing. With rigidity accounted for, the SZ group was significantly more impaired than the PD group on motor sequencing; cognitive and motor processes contributed to the motor deficit. Cognitive sequencing performance predicted motor sequencing performance in PD but not SZ. Although both SZ and PD resulted in significant motor and cognitive sequencing deficits, the pattern and correlates of these deficits differ, suggesting that the affected neural systems underlying motor deficits in SZ are different from those involved in PD.
ISSN:0894-4105
1931-1559
DOI:10.1037/0894-4105.15.3.342