CD8-positive tumor-infiltrating lymphocytes influence the long-term survival of patients with mycosis fungoides

Background: Nonneoplastic mononuclear cells commonly infiltrate lesions of mycosis fungoides. Objective: We sought to determine the immunophenotypic characteristics of these cells and to determine whether the presence of CD8 + tumor-infiltrating lymphocytes has an impact on prognosis. Methods: Skin...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 1995-03, Vol.32 (3), p.448-453
Main Authors: Hoppe, Richard T, Medeiros, L.Jeffrey, Warnke, Roger A, Wood, Gary S
Format: Article
Language:English
Subjects:
Actuarial Analysis
AIDS/HIV
Biological and medical sciences
CD8-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - pathology
Hematologic and hematopoietic diseases
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphocytes, Tumor-Infiltrating
Medical sciences
Multivariate Analysis
Mycosis Fungoides - immunology
Mycosis Fungoides - mortality
Mycosis Fungoides - pathology
Prognosis
Survival Rate
Time Factors
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Summary:Background: Nonneoplastic mononuclear cells commonly infiltrate lesions of mycosis fungoides. Objective: We sought to determine the immunophenotypic characteristics of these cells and to determine whether the presence of CD8 + tumor-infiltrating lymphocytes has an impact on prognosis. Methods: Skin biopsy specimens from 78 patients were stained with immunopleroxidase techniques to determine their phenotypic characteristics. The proportion of CD8 + tumor-infiltrating lymphocytes was quantified and compared with stage of disease and survival rate. Results: Patients with more limited T-stage disease tended to have a higher proportion of CD8 + cells in their skin biopsy specimens, compared with patients with more advanced T-stage disease. Within each T-stage patients with a larger proportion of CD8 + cells had a better survival rate than those with fewer CD8 + cells ( p < 0.05 for T1 and T3). A multivariate analysis confirmed the importance of T stage ( p = 0.0006), overal stage ( p = 0.0112), and CD8 positivity ( p = 0.0335) in this cohort of patients. Conclusion: CD8 + tumor-infiltrating lymphocytes in mycosis fungoides correlate with improved survival rate and may exert an antitumor effect rather than being mere bystander cells.
ISSN:0190-9622
1097-6787
DOI:10.1016/0190-9622(95)90067-5