The morphology of xenotransplanted human breast carcinoma MX-1 growing in nude mice. A light and transmission electron microscopic study

The present investigation is concerned with the morphological features of the human breast carcinoma MX-1, transplanted subcutaneously into nude mice. Three weeks after transplantation the tumor tissue is clearly distinct from the dermis. Solid tumor cell groups are separated incompletely by thin co...

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Bibliographic Details
Published in:Annals of anatomy 1995-01, Vol.177 (1), p.3-10
Main Authors: Mendoza, Andrés S., Mentzel, Martin, Krüger, Matthias, Krammer, Heinz J., Wiedemann, Günter, Wagner, Thomas, Weiss, Christoph, Kühnel, Wolfgang
Format: Article
Language:English
Subjects:
Animals
Breast Neoplasms - blood supply
Breast Neoplasms - pathology
Breast Neoplasms - ultrastructure
Capillaries - pathology
Capillaries - ultrastructure
Cell Line
Experimental tumor
Female
Human breast carcinoma
Humans
Light microscopy
Mice
Mice, Nude
Microscopy, Electron
MX-1
Nerve Fibers - pathology
Nerve Fibers - ultrastructure
Nude mice
Transmission electron microscopy
Transplantation, Heterologous
Tumor Cells, Cultured
Xenotransplant
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Summary:The present investigation is concerned with the morphological features of the human breast carcinoma MX-1, transplanted subcutaneously into nude mice. Three weeks after transplantation the tumor tissue is clearly distinct from the dermis. Solid tumor cell groups are separated incompletely by thin connective tissue septa, giving rise to a lobular appearance. The tumor cells are characterized by very irregularly formed nuclei with three or more nucleoli. The cytoplasm of these cells displays some lysosomes, the cisternae of the rough endoplasmic reticulum, mitochondria and a variable number of ribosomes. The Golgi fields are frequently observed, particularly near the nucleus. The cells are connected to each other by desmosomes, which also persist during mitotic activity. Ductular formations can occasionally be seen. The ultrastructure of the blood vessels discloses the morphological features necessary for the regulation of blood flow. Capillaries present a sinusoidal aspect with distended and narrow lumina. Interruptions of the endothelial wall, however, were not observed. This morphological appearance was found in all the MX-1 tumors investigated, reflecting the stable growthof this tumor cell line in nude mice.
ISSN:0940-9602
1618-0402
DOI:10.1016/S0940-9602(11)80122-6