Docosahexaenoic Acid Is a Potent Inhibitor of Rat Uterine Stromal Cell Proliferation

The effect of different families of fatty acids on the proliferation of rat uterine stromal cells (U III) was studied. Docosahexaenoic acid (DHA) exerted a strong and dose-dependent inhibitory effect (IC 50 ∼ 2 μM), whereas arachidonic acid (AA) stimulated U III cell proliferation at the optimal con...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 1995-02, Vol.207 (3), p.1015-1021
Main Authors: Tessier, C., Fayard, J.M., Cohen, H., Pageaux, J.F., Lagarde, M., Laugier, C.
Format: Article
Language:English
Subjects:
Animals
Arachidonic Acid - pharmacology
Butylated Hydroxytoluene - pharmacology
Cell Division - drug effects
Cells, Cultured
DNA - biosynthesis
Docosahexaenoic Acids - administration & dosage
Docosahexaenoic Acids - pharmacology
Dose-Response Relationship, Drug
Fatty Acids - pharmacology
Female
Lipid Peroxidation - drug effects
Rats
Stromal Cells - cytology
Uterus - cytology
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Summary:The effect of different families of fatty acids on the proliferation of rat uterine stromal cells (U III) was studied. Docosahexaenoic acid (DHA) exerted a strong and dose-dependent inhibitory effect (IC 50 ∼ 2 μM), whereas arachidonic acid (AA) stimulated U III cell proliferation at the optimal concentration of 10 μM. Oleic, linoleic and linolenic acids were ineffective from 0.1 to 10 μM. The inhibitory effect of DHA was independent of the eicosanoid biosynthesis and lipid peroxidation, since it was not reversed by the addition of the antioxidant BHT and no significant production of oxidized species from DHA occurred in our culture conditions.
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1995.1286