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Docosahexaenoic Acid Is a Potent Inhibitor of Rat Uterine Stromal Cell Proliferation
The effect of different families of fatty acids on the proliferation of rat uterine stromal cells (U III) was studied. Docosahexaenoic acid (DHA) exerted a strong and dose-dependent inhibitory effect (IC 50 ∼ 2 μM), whereas arachidonic acid (AA) stimulated U III cell proliferation at the optimal con...
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Published in: | Biochemical and biophysical research communications 1995-02, Vol.207 (3), p.1015-1021 |
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container_title | Biochemical and biophysical research communications |
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creator | Tessier, C. Fayard, J.M. Cohen, H. Pageaux, J.F. Lagarde, M. Laugier, C. |
description | The effect of different families of fatty acids on the proliferation of rat uterine stromal cells (U
III) was studied. Docosahexaenoic acid (DHA) exerted a strong and dose-dependent inhibitory effect (IC
50 ∼ 2 μM), whereas arachidonic acid (AA) stimulated U
III cell proliferation at the optimal concentration of 10 μM. Oleic, linoleic and linolenic acids were ineffective from 0.1 to 10 μM. The inhibitory effect of DHA was independent of the eicosanoid biosynthesis and lipid peroxidation, since it was not reversed by the addition of the antioxidant BHT and no significant production of oxidized species from DHA occurred in our culture conditions. |
doi_str_mv | 10.1006/bbrc.1995.1286 |
format | article |
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III) was studied. Docosahexaenoic acid (DHA) exerted a strong and dose-dependent inhibitory effect (IC
50 ∼ 2 μM), whereas arachidonic acid (AA) stimulated U
III cell proliferation at the optimal concentration of 10 μM. Oleic, linoleic and linolenic acids were ineffective from 0.1 to 10 μM. The inhibitory effect of DHA was independent of the eicosanoid biosynthesis and lipid peroxidation, since it was not reversed by the addition of the antioxidant BHT and no significant production of oxidized species from DHA occurred in our culture conditions.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1006/bbrc.1995.1286</identifier><identifier>PMID: 7864887</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Arachidonic Acid - pharmacology ; Butylated Hydroxytoluene - pharmacology ; Cell Division - drug effects ; Cells, Cultured ; DNA - biosynthesis ; Docosahexaenoic Acids - administration & dosage ; Docosahexaenoic Acids - pharmacology ; Dose-Response Relationship, Drug ; Fatty Acids - pharmacology ; Female ; Lipid Peroxidation - drug effects ; Rats ; Stromal Cells - cytology ; Uterus - cytology</subject><ispartof>Biochemical and biophysical research communications, 1995-02, Vol.207 (3), p.1015-1021</ispartof><rights>1995 Academic Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-c357e0f63d65488be00ddbf2326a6af16d44196fd0c6bbbd939dbf0d96e756453</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7864887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tessier, C.</creatorcontrib><creatorcontrib>Fayard, J.M.</creatorcontrib><creatorcontrib>Cohen, H.</creatorcontrib><creatorcontrib>Pageaux, J.F.</creatorcontrib><creatorcontrib>Lagarde, M.</creatorcontrib><creatorcontrib>Laugier, C.</creatorcontrib><title>Docosahexaenoic Acid Is a Potent Inhibitor of Rat Uterine Stromal Cell Proliferation</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>The effect of different families of fatty acids on the proliferation of rat uterine stromal cells (U
III) was studied. Docosahexaenoic acid (DHA) exerted a strong and dose-dependent inhibitory effect (IC
50 ∼ 2 μM), whereas arachidonic acid (AA) stimulated U
III cell proliferation at the optimal concentration of 10 μM. Oleic, linoleic and linolenic acids were ineffective from 0.1 to 10 μM. The inhibitory effect of DHA was independent of the eicosanoid biosynthesis and lipid peroxidation, since it was not reversed by the addition of the antioxidant BHT and no significant production of oxidized species from DHA occurred in our culture conditions.</description><subject>Animals</subject><subject>Arachidonic Acid - pharmacology</subject><subject>Butylated Hydroxytoluene - pharmacology</subject><subject>Cell Division - drug effects</subject><subject>Cells, Cultured</subject><subject>DNA - biosynthesis</subject><subject>Docosahexaenoic Acids - administration & dosage</subject><subject>Docosahexaenoic Acids - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fatty Acids - pharmacology</subject><subject>Female</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Rats</subject><subject>Stromal Cells - cytology</subject><subject>Uterus - cytology</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNp1kEtLAzEUhYMotVa37oSs3E1N5pGZLEt9FQoWbcFdyOMOjUwnNUlF_70pLe7c3Ls45x7O_RC6pmRMCWF3Snk9ppxXY5o37AQNKeEkyykpT9GQJEeWc_p-ji5C-CCE0pLxARrUDSubph6i5b3TLsg1fEvondV4oq3Bs4AlXrgIfcSzfm2Vjc5j1-JXGfEqgrc94Lfo3UZ2eApdhxfedbYFL6N1_SU6a2UX4Oq4R2j1-LCcPmfzl6fZdDLPdFHwmGZVA2lZYViV2iggxBjV5kXOJJMtZaYsKWetIZoppQwveJKJ4QzqipVVMUK3h9ytd587CFFsbNCpjuzB7YKoa8oIZXkyjg9G7V0IHlqx9XYj_Y-gROwxij1Gscco9hjTwc0xeac2YP7sR25Jbw46pPe-LHgRtIVeg7EedBTG2f-ifwHWOYGM</recordid><startdate>19950227</startdate><enddate>19950227</enddate><creator>Tessier, C.</creator><creator>Fayard, J.M.</creator><creator>Cohen, H.</creator><creator>Pageaux, J.F.</creator><creator>Lagarde, M.</creator><creator>Laugier, C.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950227</creationdate><title>Docosahexaenoic Acid Is a Potent Inhibitor of Rat Uterine Stromal Cell Proliferation</title><author>Tessier, C. ; Fayard, J.M. ; Cohen, H. ; Pageaux, J.F. ; Lagarde, M. ; Laugier, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-c357e0f63d65488be00ddbf2326a6af16d44196fd0c6bbbd939dbf0d96e756453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Arachidonic Acid - pharmacology</topic><topic>Butylated Hydroxytoluene - pharmacology</topic><topic>Cell Division - drug effects</topic><topic>Cells, Cultured</topic><topic>DNA - biosynthesis</topic><topic>Docosahexaenoic Acids - administration & dosage</topic><topic>Docosahexaenoic Acids - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fatty Acids - pharmacology</topic><topic>Female</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Rats</topic><topic>Stromal Cells - cytology</topic><topic>Uterus - cytology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tessier, C.</creatorcontrib><creatorcontrib>Fayard, J.M.</creatorcontrib><creatorcontrib>Cohen, H.</creatorcontrib><creatorcontrib>Pageaux, J.F.</creatorcontrib><creatorcontrib>Lagarde, M.</creatorcontrib><creatorcontrib>Laugier, C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tessier, C.</au><au>Fayard, J.M.</au><au>Cohen, H.</au><au>Pageaux, J.F.</au><au>Lagarde, M.</au><au>Laugier, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Docosahexaenoic Acid Is a Potent Inhibitor of Rat Uterine Stromal Cell Proliferation</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1995-02-27</date><risdate>1995</risdate><volume>207</volume><issue>3</issue><spage>1015</spage><epage>1021</epage><pages>1015-1021</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>The effect of different families of fatty acids on the proliferation of rat uterine stromal cells (U
III) was studied. Docosahexaenoic acid (DHA) exerted a strong and dose-dependent inhibitory effect (IC
50 ∼ 2 μM), whereas arachidonic acid (AA) stimulated U
III cell proliferation at the optimal concentration of 10 μM. Oleic, linoleic and linolenic acids were ineffective from 0.1 to 10 μM. The inhibitory effect of DHA was independent of the eicosanoid biosynthesis and lipid peroxidation, since it was not reversed by the addition of the antioxidant BHT and no significant production of oxidized species from DHA occurred in our culture conditions.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7864887</pmid><doi>10.1006/bbrc.1995.1286</doi><tpages>7</tpages></addata></record> |
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language | eng |
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source | ScienceDirect Journals |
subjects | Animals Arachidonic Acid - pharmacology Butylated Hydroxytoluene - pharmacology Cell Division - drug effects Cells, Cultured DNA - biosynthesis Docosahexaenoic Acids - administration & dosage Docosahexaenoic Acids - pharmacology Dose-Response Relationship, Drug Fatty Acids - pharmacology Female Lipid Peroxidation - drug effects Rats Stromal Cells - cytology Uterus - cytology |
title | Docosahexaenoic Acid Is a Potent Inhibitor of Rat Uterine Stromal Cell Proliferation |
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