Calmodulin-binding domains: just two faced or multi-faceted?

The Ca 2+-binding protein calmodulin binds to and activates several cellular enzymes in response to a rise in Ca 2+ concentration. It binds certain basic amphiphilic helices within these enzymes, which also act as autoinhibitory domains. The modulation of the binding equilibrium of these helices bet...

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Bibliographic Details
Published in:Trends in Biochemical Sciences 1995, Vol.20 (1), p.38-42
Main Authors: James, Peter, Vorherr, Thomas, Carafoli, Ernesto
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Calmodulin-Binding Proteins - chemistry
Calmodulin-Binding Proteins - physiology
Models, Molecular
Molecular Sequence Data
Protein Structure, Tertiary
Structure-Activity Relationship
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Summary:The Ca 2+-binding protein calmodulin binds to and activates several cellular enzymes in response to a rise in Ca 2+ concentration. It binds certain basic amphiphilic helices within these enzymes, which also act as autoinhibitory domains. The modulation of the binding equilibrium of these helices between intramolecular (inhibition) and intermolecular (activation) sites forms a focal point for crosstalk between various signalling pathways.
ISSN:0968-0004
1362-4326
DOI:10.1016/S0968-0004(00)88949-5