Tumorous manifestation of hairy cell leukemia after long-term treatment with interferon alpha

Tumorous-manifestation of hairy cell leukemia in a patient treated with IFN alpha for 7 years is described. After this time, while the patient still was in hematological remission, a tumorous involvement of the lung by hairy cells developed and was successfully treated by surgery. No differences in...

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Bibliographic Details
Published in:Annals of hematology 1995-02, Vol.70 (2), p.103-105
Main Authors: HUHN, D, OERTEL, J, SERKE, S, KAISER, D, SCHMITT-GRÄFF, A, STEIN, H
Format: Article
Language:English
Subjects:
Antineoplastic agents
Biological and medical sciences
Bone Marrow - pathology
Dose-Response Relationship, Drug
Humans
Immunotherapy
Interferon-alpha - therapeutic use
Leukemia, Hairy Cell - complications
Leukemia, Hairy Cell - drug therapy
Leukemia, Hairy Cell - pathology
Lung - pathology
Lung Neoplasms - diagnosis
Lung Neoplasms - etiology
Lung Neoplasms - pathology
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Time Factors
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Summary:Tumorous-manifestation of hairy cell leukemia in a patient treated with IFN alpha for 7 years is described. After this time, while the patient still was in hematological remission, a tumorous involvement of the lung by hairy cells developed and was successfully treated by surgery. No differences in the phenotype of hairy cells in the lung tumor, in the bone marrow, or in the blood could be detected.
ISSN:0939-5555
1432-0584
DOI:10.1007/BF01834389