The influence of low arylsulfatase A activity on neuropsychiatric morbidity: a large-scale screening in patients

A total of 1728 patients consecutively admitted to a neuropsychiatric hospital and 379 chronically ill inpatients were examined for activity of arylsulphatase A (ASA) in leucocytes. A further 519 healthy individuals served as controls. We did not find evidence for the involvement of low ASA activity...

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Bibliographic Details
Published in:Human genetics 1986-11, Vol.74 (3), p.244-248
Main Authors: PROPPING, P, FRIEDL, W, HUSCHKA, M, SCHLÖR, K.-H, REIMER, F, LEE-VAUPEL, M, CONZELMANN, E, SANDHOFF, K
Format: Article
Language:English
Subjects:
Alleles
Biological and medical sciences
Cerebroside-Sulfatase - blood
Cerebroside-Sulfatase - deficiency
Cerebroside-Sulfatase - genetics
Heterozygote
Humans
Inpatients
Leukodystrophy, Metachromatic - complications
Leukodystrophy, Metachromatic - enzymology
Leukodystrophy, Metachromatic - genetics
Mass Screening
Medical sciences
Mental Disorders - enzymology
Mental Disorders - etiology
Miscellaneous
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Risk
Techniques and methods
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Summary:A total of 1728 patients consecutively admitted to a neuropsychiatric hospital and 379 chronically ill inpatients were examined for activity of arylsulphatase A (ASA) in leucocytes. A further 519 healthy individuals served as controls. We did not find evidence for the involvement of low ASA activity in chronic patients. The consecutive admissions showed a slight preponderance in the lower ASA activity classes. This activity range covers persons heterozygous for ASA deficiency alleles. The data are compatible with the hypothesis that carriers of low ASA activity alleles are at a slightly higher risk for neuropsychiatric disorders.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00282542