Effect of the delivery system on the biodistribution on Ge(IV) octabutoxy-phthalocyanines in tumour-bearing mice

The pharmacokinetic properties of the Ge(IV)-octabutoxy-phthalocyanines (GePc) with two axially ligated triethylsiloxy (GePcEt) or trihexyl-siloxy (GePcHex) chains were studied in BALB/C mice bearing a transplanted MS-2 fibrosarcoma. The GePcs were delivered to mice after incorporation into unilamel...

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Bibliographic Details
Published in:Cancer letters 1995-02, Vol.89 (1), p.101-106
Main Authors: SONCIN, M, POLO, L, REDDI, E, JORI, G, KENNEY, M. E, CHENG, G, RODGERS, M. A. J
Format: Article
Language:English
Subjects:
1,2-Dipalmitoylphosphatidylcholine
Animals
Biological and medical sciences
Disease Models, Animal
Drug Carriers
Emulsions
Female
Glycerol - analogs & derivatives
Indoles - administration & dosage
Indoles - pharmacokinetics
Liposomes
Liver - metabolism
Medical sciences
Mice
Mice, Inbred BALB C
Neoplasms, Experimental - metabolism
Organometallic Compounds - administration & dosage
Organometallic Compounds - pharmacokinetics
Photoradiation therapy and photosensitizing agent
Photosensitizing Agents - administration & dosage
Photosensitizing Agents - pharmacokinetics
Spleen - metabolism
Tissue Distribution
Treatment with physical agents
Treatment. General aspects
Tumors
Citations: Items that cite this one
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Summary:The pharmacokinetic properties of the Ge(IV)-octabutoxy-phthalocyanines (GePc) with two axially ligated triethylsiloxy (GePcEt) or trihexyl-siloxy (GePcHex) chains were studied in BALB/C mice bearing a transplanted MS-2 fibrosarcoma. The GePcs were delivered to mice after incorporation into unilamellar liposomes of dipalmitoyl phosphatidylcholine (DPPC) or in an emulsion of Cremophor-EL. The Cremophor delivered GePcs were cleared from the blood circulation at a much slower rate than the liposome-delivered GePcs. At the same time, Cremophor induced a slower and reduced uptake of the GePcs in the liver and spleen while it greatly enhanced the uptake in the tumour as compared to liposomes. Maximum tumour uptake was observed at 24 h post-injection and was equivalent to 0.67 and 0.50 nmol/g, respectively, for the Cremophor delivered GePcHex and GePcEt. The corresponding values for the liposome-delivered drugs were approximately one fourth of that observed with Cremophor.
ISSN:0304-3835
1872-7980
DOI:10.1016/0304-3835(94)03655-3