PROPIOXATINS A AND B, NEW ENKEPHALINASE B INHIBITORS: II. STRUCTURAL ELUCIDATION

The structures of propioxatins A (C17H29N3O6) and B (C18H31N3O6), new enkephalinase B inhibitors produced by Kitasatosporia setae SANK 60684, were determined. Both propioxatins consist of N-acyl-L-prolyl-L-valine. N-Acyl moieties of propioxatins A and B were α-propyl and α-isobutyl succinic acid β-h...

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Bibliographic Details
Published in:Journal of antibiotics 1986, Vol.39(10), pp.1378-1381
Main Authors: INAOKA, YOSHINORI, TAKAHASHI, SHUJI, KINOSHITA, TAKESHI
Format: Article
Language:English
Subjects:
Chemical Phenomena
Chemistry
Dipeptides
Hydrolysis
Protease Inhibitors
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Summary:The structures of propioxatins A (C17H29N3O6) and B (C18H31N3O6), new enkephalinase B inhibitors produced by Kitasatosporia setae SANK 60684, were determined. Both propioxatins consist of N-acyl-L-prolyl-L-valine. N-Acyl moieties of propioxatins A and B were α-propyl and α-isobutyl succinic acid β-hydroxamic acid, respectively.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.39.1378