Review of the macrophage disappearance reaction

Macrophages (Mφs) undergo a physiological response known as the macrophage disappearance reaction (MDR) in response to certain stimuli in the peritoneal compartment. The types of stimuli that can cause the MDR, the relationship of the MDR to the host immunological response, and the possible role of...

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Bibliographic Details
Published in:Journal of leukocyte biology 1995-03, Vol.57 (3), p.361-367
Main Authors: Barth, Malcolm W., Hendrzak, Jill A., Melnicoff, Meryle J., Morahan, Page S.
Format: Article
Language:English
Subjects:
Acute Disease
Animals
delayed‐type hypersensitivity
Exudates and Transudates
Hypersensitivity, Delayed - immunology
Hypersensitivity, Delayed - pathology
inflammation
Inflammation - pathology
Inflammation - physiopathology
Macrophage Activation
Macrophages, Peritoneal - immunology
phagocyte
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Summary:Macrophages (Mφs) undergo a physiological response known as the macrophage disappearance reaction (MDR) in response to certain stimuli in the peritoneal compartment. The types of stimuli that can cause the MDR, the relationship of the MDR to the host immunological response, and the possible role of the MDR in Mφ activation are reviewed. The data indicate that the MDR occurs in response to both acute nonspecific inflammatory and specific immune delayed hypersensitivity processes and that the MDR may play an important role in Mφ activation. J. Leukoc. Biol. 57: 361–367; 1995.
ISSN:0741-5400
1938-3673
DOI:10.1002/jlb.57.3.361