Gaudichanolides A and B, Clerodane Diterpenes from Baccharis gaudichaudiana

Two new clerodane diterpenoids, gaudichanolides A (1) and B (2), were isolated from the dried twigs of Baccharis gaudichaudiana, together with 7-oxo-16,19-dihydroxy-3,4-dehydroclerodan-15,20-diacid dilactone, spathulenol, 4,10-aromadendranediol, kobusone, trans-cosanyl ferulate, and defuscin. The st...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2005-07, Vol.68 (7), p.1121-1124
Main Authors: Hayashi, Ken-ichiro, Kanamori, Takashi, Yamazoe, Atsushi, Yamada, Masashi, Nozaki, Hiroshi
Format: Article
Language:English
Subjects:
Baccharis
Baccharis - chemistry
Baccharis gaudichaudiana
Biological and medical sciences
Brazil
chemical structure
clerodane
Crystallography, X-Ray
Diterpenes, Clerodane - chemistry
Diterpenes, Clerodane - isolation & purification
diterpenoids
gaudichanolides
General pharmacology
Medical sciences
medicinal plants
Molecular Conformation
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
phytochemicals
plant extracts
Plants, Medicinal - chemistry
spectral analysis
stereochemistry
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Summary:Two new clerodane diterpenoids, gaudichanolides A (1) and B (2), were isolated from the dried twigs of Baccharis gaudichaudiana, together with 7-oxo-16,19-dihydroxy-3,4-dehydroclerodan-15,20-diacid dilactone, spathulenol, 4,10-aromadendranediol, kobusone, trans-cosanyl ferulate, and defuscin. The structures and relative stereochemistry of 1 and 2 were elucidated by detailed 2D NMR spectroscopic experiments, and the absolute stereochemistry of 1 was determined by X-ray crystallographic analysis.
ISSN:0163-3864
1520-6025
DOI:10.1021/np050081i