Antidiabetic effects of extracts from Psidium guajava

• Published in: Journal of ethnopharmacology 2005-01, Vol.96 (3), p.411-415
• Main Authors: Oh, Won Keun, Lee, Chul Ho, Lee, Myung Sun, Bae, Eun Young, Sohn, Cheon Bae, Oh, Hyuncheol, Kim, Bo Yeon, Ahn, Jong Seog
• Format: Article
• Language: English
• Subjects: Age Factors; animal disease models; Animals; Biological and medical sciences; Blood glucose; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - drug therapy; Disease Models, Animal; enzyme inhibitors; Fatty Liver - complications; Fatty Liver - drug therapy; Fatty Liver - pathology; Female; General pharmacology; glycemic effect; Hypoglycemic Agents - therapeutic use; Injections, Intraperitoneal; leaves; Leprdb/ Leprdb mice; Male; Medical sciences; medicinal plants; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; noninsulin-dependent diabetes mellitus; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; phosphoric monoester hydrolases; Phytotherapy; plant extracts; Plant Extracts - chemistry; Plant Extracts - therapeutic use; Plant Leaves - chemistry; protein-tyrosine-phosphatase1B; Psidium; Psidium guajava; PTP1B; Type 2 diabetes
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/j.jep.2004.09.041

During a screening of medicinal plants for inhibition of protein tyrosine phosphatase1B (PTP1B), an extract from Psidium guajava (Myrtaceae) leaves exhibited significant inhibitory effect on PTP1B. Thus, its antidiabetic effect on Lepr db / Lepr db mice was evaluated. Significant blood glucose lowering effects of the extract were observed after intraperitoneal injection of the extract at a dose of 10 mg/kg in both 1- and 3-month-old Lepr db / Lepr db mice. In addition, histological analysis of the liver from the butanol-soluble fraction treated Lepr db / Lepr db mice revealed a significant decrease in the number of lipid droplets compared to the control mice. Taken together, it was suggested that the extract from Psidium guajava leaves possesses antidiabetic effect in type 2 diabetic mice model and these effect is, at least in part, mediated via the inhibition of PTP1B.