Loading…
Antidiabetic effects of extracts from Psidium guajava
During a screening of medicinal plants for inhibition of protein tyrosine phosphatase1B (PTP1B), an extract from Psidium guajava (Myrtaceae) leaves exhibited significant inhibitory effect on PTP1B. Thus, its antidiabetic effect on Lepr db / Lepr db mice was evaluated. Significant blood glucose lower...
Saved in:
| Published in: | Journal of ethnopharmacology 2005-01, Vol.96 (3), p.411-415 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c503t-b026c1a4ac7918bc1278339c324860089d74d2514a65a2951804910c617d320c3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c503t-b026c1a4ac7918bc1278339c324860089d74d2514a65a2951804910c617d320c3 |
| container_end_page | 415 |
| container_issue | 3 |
| container_start_page | 411 |
| container_title | Journal of ethnopharmacology |
| container_volume | 96 |
| creator | Oh, Won Keun Lee, Chul Ho Lee, Myung Sun Bae, Eun Young Sohn, Cheon Bae Oh, Hyuncheol Kim, Bo Yeon Ahn, Jong Seog |
| description | During a screening of medicinal plants for inhibition of protein tyrosine phosphatase1B (PTP1B), an extract from
Psidium guajava (Myrtaceae) leaves exhibited significant inhibitory effect on PTP1B. Thus, its antidiabetic effect on
Lepr
db
/
Lepr
db
mice was evaluated. Significant blood glucose lowering effects of the extract were observed after intraperitoneal injection of the extract at a dose of 10
mg/kg in both 1- and 3-month-old
Lepr
db
/
Lepr
db
mice. In addition, histological analysis of the liver from the butanol-soluble fraction treated
Lepr
db
/
Lepr
db
mice revealed a significant decrease in the number of lipid droplets compared to the control mice. Taken together, it was suggested that the extract from
Psidium guajava leaves possesses antidiabetic effect in type 2 diabetic mice model and these effect is, at least in part, mediated via the inhibition of PTP1B. |
| doi_str_mv | 10.1016/j.jep.2004.09.041 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_771698046</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378874104004660</els_id><sourcerecordid>771698046</sourcerecordid><originalsourceid>FETCH-LOGICAL-c503t-b026c1a4ac7918bc1278339c324860089d74d2514a65a2951804910c617d320c3</originalsourceid><addsrcrecordid>eNp90U1v1DAQgGELFdFt4QdwgVwop6Qz_ozFqapaQKoEUunZmnWcytFms7WTCv49Xu1KvfVkH56x7NeMfURoEFBfDs0Qdg0HkA3YBiS-YStsDa-NMuKErUCYtm6NxFN2lvMAAAYlvGOnqDRapeyKqavtHLtI6zBHX4W-D37O1dRX4e-caL_v0zRWv3NBy1g9LjTQM71nb3va5PDhuJ6zh9ubP9c_6rtf339eX93VXoGY6zVw7ZEkeWOxXXvkphXCesFlqwFa2xnZcYWStCJuFbYgLYLXaDrBwYtz9vVw7i5NT0vIsxtj9mGzoW2YluyMQW3LkC7y4lWpjZDSClsgHqBPU84p9G6X4kjpn0Nw-6pucKWq21d1YF2pWmY-HQ9f1mPoXiaOGQv4cgSUPW36RFsf84vTEkR5X3GfD66nydFjKubhngMKwJJDoizi20GEkvU5huSyj2HrQxdT-RrXTfGVi_4HERaamg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67344939</pqid></control><display><type>article</type><title>Antidiabetic effects of extracts from Psidium guajava</title><source>ScienceDirect Freedom Collection</source><creator>Oh, Won Keun ; Lee, Chul Ho ; Lee, Myung Sun ; Bae, Eun Young ; Sohn, Cheon Bae ; Oh, Hyuncheol ; Kim, Bo Yeon ; Ahn, Jong Seog</creator><creatorcontrib>Oh, Won Keun ; Lee, Chul Ho ; Lee, Myung Sun ; Bae, Eun Young ; Sohn, Cheon Bae ; Oh, Hyuncheol ; Kim, Bo Yeon ; Ahn, Jong Seog</creatorcontrib><description>During a screening of medicinal plants for inhibition of protein tyrosine phosphatase1B (PTP1B), an extract from
Psidium guajava (Myrtaceae) leaves exhibited significant inhibitory effect on PTP1B. Thus, its antidiabetic effect on
Lepr
db
/
Lepr
db
mice was evaluated. Significant blood glucose lowering effects of the extract were observed after intraperitoneal injection of the extract at a dose of 10
mg/kg in both 1- and 3-month-old
Lepr
db
/
Lepr
db
mice. In addition, histological analysis of the liver from the butanol-soluble fraction treated
Lepr
db
/
Lepr
db
mice revealed a significant decrease in the number of lipid droplets compared to the control mice. Taken together, it was suggested that the extract from
Psidium guajava leaves possesses antidiabetic effect in type 2 diabetic mice model and these effect is, at least in part, mediated via the inhibition of PTP1B.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2004.09.041</identifier><identifier>PMID: 15619559</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Age Factors ; animal disease models ; Animals ; Biological and medical sciences ; Blood glucose ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - drug therapy ; Disease Models, Animal ; enzyme inhibitors ; Fatty Liver - complications ; Fatty Liver - drug therapy ; Fatty Liver - pathology ; Female ; General pharmacology ; glycemic effect ; Hypoglycemic Agents - therapeutic use ; Injections, Intraperitoneal ; leaves ; Leprdb/ Leprdb mice ; Male ; Medical sciences ; medicinal plants ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; noninsulin-dependent diabetes mellitus ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; phosphoric monoester hydrolases ; Phytotherapy ; plant extracts ; Plant Extracts - chemistry ; Plant Extracts - therapeutic use ; Plant Leaves - chemistry ; protein-tyrosine-phosphatase1B ; Psidium ; Psidium guajava ; PTP1B ; Type 2 diabetes</subject><ispartof>Journal of ethnopharmacology, 2005-01, Vol.96 (3), p.411-415</ispartof><rights>2004 Elsevier Ireland Ltd</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-b026c1a4ac7918bc1278339c324860089d74d2514a65a2951804910c617d320c3</citedby><cites>FETCH-LOGICAL-c503t-b026c1a4ac7918bc1278339c324860089d74d2514a65a2951804910c617d320c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16403295$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15619559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oh, Won Keun</creatorcontrib><creatorcontrib>Lee, Chul Ho</creatorcontrib><creatorcontrib>Lee, Myung Sun</creatorcontrib><creatorcontrib>Bae, Eun Young</creatorcontrib><creatorcontrib>Sohn, Cheon Bae</creatorcontrib><creatorcontrib>Oh, Hyuncheol</creatorcontrib><creatorcontrib>Kim, Bo Yeon</creatorcontrib><creatorcontrib>Ahn, Jong Seog</creatorcontrib><title>Antidiabetic effects of extracts from Psidium guajava</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>During a screening of medicinal plants for inhibition of protein tyrosine phosphatase1B (PTP1B), an extract from
Psidium guajava (Myrtaceae) leaves exhibited significant inhibitory effect on PTP1B. Thus, its antidiabetic effect on
Lepr
db
/
Lepr
db
mice was evaluated. Significant blood glucose lowering effects of the extract were observed after intraperitoneal injection of the extract at a dose of 10
mg/kg in both 1- and 3-month-old
Lepr
db
/
Lepr
db
mice. In addition, histological analysis of the liver from the butanol-soluble fraction treated
Lepr
db
/
Lepr
db
mice revealed a significant decrease in the number of lipid droplets compared to the control mice. Taken together, it was suggested that the extract from
Psidium guajava leaves possesses antidiabetic effect in type 2 diabetic mice model and these effect is, at least in part, mediated via the inhibition of PTP1B.</description><subject>Age Factors</subject><subject>animal disease models</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood glucose</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Disease Models, Animal</subject><subject>enzyme inhibitors</subject><subject>Fatty Liver - complications</subject><subject>Fatty Liver - drug therapy</subject><subject>Fatty Liver - pathology</subject><subject>Female</subject><subject>General pharmacology</subject><subject>glycemic effect</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Injections, Intraperitoneal</subject><subject>leaves</subject><subject>Leprdb/ Leprdb mice</subject><subject>Male</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Mutant Strains</subject><subject>noninsulin-dependent diabetes mellitus</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>phosphoric monoester hydrolases</subject><subject>Phytotherapy</subject><subject>plant extracts</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Leaves - chemistry</subject><subject>protein-tyrosine-phosphatase1B</subject><subject>Psidium</subject><subject>Psidium guajava</subject><subject>PTP1B</subject><subject>Type 2 diabetes</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNp90U1v1DAQgGELFdFt4QdwgVwop6Qz_ozFqapaQKoEUunZmnWcytFms7WTCv49Xu1KvfVkH56x7NeMfURoEFBfDs0Qdg0HkA3YBiS-YStsDa-NMuKErUCYtm6NxFN2lvMAAAYlvGOnqDRapeyKqavtHLtI6zBHX4W-D37O1dRX4e-caL_v0zRWv3NBy1g9LjTQM71nb3va5PDhuJ6zh9ubP9c_6rtf339eX93VXoGY6zVw7ZEkeWOxXXvkphXCesFlqwFa2xnZcYWStCJuFbYgLYLXaDrBwYtz9vVw7i5NT0vIsxtj9mGzoW2YluyMQW3LkC7y4lWpjZDSClsgHqBPU84p9G6X4kjpn0Nw-6pucKWq21d1YF2pWmY-HQ9f1mPoXiaOGQv4cgSUPW36RFsf84vTEkR5X3GfD66nydFjKubhngMKwJJDoizi20GEkvU5huSyj2HrQxdT-RrXTfGVi_4HERaamg</recordid><startdate>20050115</startdate><enddate>20050115</enddate><creator>Oh, Won Keun</creator><creator>Lee, Chul Ho</creator><creator>Lee, Myung Sun</creator><creator>Bae, Eun Young</creator><creator>Sohn, Cheon Bae</creator><creator>Oh, Hyuncheol</creator><creator>Kim, Bo Yeon</creator><creator>Ahn, Jong Seog</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050115</creationdate><title>Antidiabetic effects of extracts from Psidium guajava</title><author>Oh, Won Keun ; Lee, Chul Ho ; Lee, Myung Sun ; Bae, Eun Young ; Sohn, Cheon Bae ; Oh, Hyuncheol ; Kim, Bo Yeon ; Ahn, Jong Seog</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-b026c1a4ac7918bc1278339c324860089d74d2514a65a2951804910c617d320c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Age Factors</topic><topic>animal disease models</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood glucose</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Disease Models, Animal</topic><topic>enzyme inhibitors</topic><topic>Fatty Liver - complications</topic><topic>Fatty Liver - drug therapy</topic><topic>Fatty Liver - pathology</topic><topic>Female</topic><topic>General pharmacology</topic><topic>glycemic effect</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Injections, Intraperitoneal</topic><topic>leaves</topic><topic>Leprdb/ Leprdb mice</topic><topic>Male</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Mutant Strains</topic><topic>noninsulin-dependent diabetes mellitus</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>phosphoric monoester hydrolases</topic><topic>Phytotherapy</topic><topic>plant extracts</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Leaves - chemistry</topic><topic>protein-tyrosine-phosphatase1B</topic><topic>Psidium</topic><topic>Psidium guajava</topic><topic>PTP1B</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oh, Won Keun</creatorcontrib><creatorcontrib>Lee, Chul Ho</creatorcontrib><creatorcontrib>Lee, Myung Sun</creatorcontrib><creatorcontrib>Bae, Eun Young</creatorcontrib><creatorcontrib>Sohn, Cheon Bae</creatorcontrib><creatorcontrib>Oh, Hyuncheol</creatorcontrib><creatorcontrib>Kim, Bo Yeon</creatorcontrib><creatorcontrib>Ahn, Jong Seog</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oh, Won Keun</au><au>Lee, Chul Ho</au><au>Lee, Myung Sun</au><au>Bae, Eun Young</au><au>Sohn, Cheon Bae</au><au>Oh, Hyuncheol</au><au>Kim, Bo Yeon</au><au>Ahn, Jong Seog</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antidiabetic effects of extracts from Psidium guajava</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2005-01-15</date><risdate>2005</risdate><volume>96</volume><issue>3</issue><spage>411</spage><epage>415</epage><pages>411-415</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>During a screening of medicinal plants for inhibition of protein tyrosine phosphatase1B (PTP1B), an extract from
Psidium guajava (Myrtaceae) leaves exhibited significant inhibitory effect on PTP1B. Thus, its antidiabetic effect on
Lepr
db
/
Lepr
db
mice was evaluated. Significant blood glucose lowering effects of the extract were observed after intraperitoneal injection of the extract at a dose of 10
mg/kg in both 1- and 3-month-old
Lepr
db
/
Lepr
db
mice. In addition, histological analysis of the liver from the butanol-soluble fraction treated
Lepr
db
/
Lepr
db
mice revealed a significant decrease in the number of lipid droplets compared to the control mice. Taken together, it was suggested that the extract from
Psidium guajava leaves possesses antidiabetic effect in type 2 diabetic mice model and these effect is, at least in part, mediated via the inhibition of PTP1B.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>15619559</pmid><doi>10.1016/j.jep.2004.09.041</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-8741 |
| ispartof | Journal of ethnopharmacology, 2005-01, Vol.96 (3), p.411-415 |
| issn | 0378-8741 1872-7573 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_771698046 |
| source | ScienceDirect Freedom Collection |
| subjects | Age Factors animal disease models Animals Biological and medical sciences Blood glucose Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Disease Models, Animal enzyme inhibitors Fatty Liver - complications Fatty Liver - drug therapy Fatty Liver - pathology Female General pharmacology glycemic effect Hypoglycemic Agents - therapeutic use Injections, Intraperitoneal leaves Leprdb/ Leprdb mice Male Medical sciences medicinal plants Mice Mice, Inbred C57BL Mice, Mutant Strains noninsulin-dependent diabetes mellitus Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phosphoric monoester hydrolases Phytotherapy plant extracts Plant Extracts - chemistry Plant Extracts - therapeutic use Plant Leaves - chemistry protein-tyrosine-phosphatase1B Psidium Psidium guajava PTP1B Type 2 diabetes |
| title | Antidiabetic effects of extracts from Psidium guajava |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T03%3A19%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antidiabetic%20effects%20of%20extracts%20from%20Psidium%20guajava&rft.jtitle=Journal%20of%20ethnopharmacology&rft.au=Oh,%20Won%20Keun&rft.date=2005-01-15&rft.volume=96&rft.issue=3&rft.spage=411&rft.epage=415&rft.pages=411-415&rft.issn=0378-8741&rft.eissn=1872-7573&rft.coden=JOETD7&rft_id=info:doi/10.1016/j.jep.2004.09.041&rft_dat=%3Cproquest_cross%3E771698046%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c503t-b026c1a4ac7918bc1278339c324860089d74d2514a65a2951804910c617d320c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=67344939&rft_id=info:pmid/15619559&rfr_iscdi=true |