ENZYMATIC CONVERSION OF 7-HYDROXYGUANINE TO ITS NUCLEOSIDES

7-Hydroxyguanine, an antitumor purine-analog, reacted with ribose (or deoxyribose)-1-phosphate in the presence of purine nucleoside phosphorylase. We prepared 7-hydroxyguanine riboside and deoxyriboside using purine nucleoside phosphorylase from bovine spleen. Each nucleoside exhibits antitumor acti...

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Bibliographic Details
Published in:Journal of antibiotics 1986, Vol.39(9), pp.1288-1290
Main Authors: KITAHARA, MIKIO, ISHII, KIYOTO, OKAZAKI, TAKESHI, HIDAKA, TAKAYOSHI, WATANABE, KIYOSHI
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - pharmacology
Biological and medical sciences
Chemical Phenomena
Chemistry
General pharmacology
Guanine - analogs & derivatives
Guanine - metabolism
Guanine - pharmacology
Medical sciences
Mice
Nucleosides - pharmacology
Pharmacology. Drug treatments
Physicochemical properties. Structure-activity relationships
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Summary:7-Hydroxyguanine, an antitumor purine-analog, reacted with ribose (or deoxyribose)-1-phosphate in the presence of purine nucleoside phosphorylase. We prepared 7-hydroxyguanine riboside and deoxyriboside using purine nucleoside phosphorylase from bovine spleen. Each nucleoside exhibits antitumor activity against mouse leukemia L1210 cells. The therapeutic effect of 7-hydroxyguanine deoxyriboside is superior to those of 7-hydroxyguanine and 7-hydroxyguanine riboside.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.39.1288