BIOSYNTHESIS OF LASALOCID A BIOCHEMICAL ALTERATION OF POLYETHER ANTIBIOTIC PRODUCTION

The effect of known precursors, their fluorinated analogs, and biochemical inhibitors on the production of the polyether antibiotic, lasalocid A (1), by resting cells of Streptomyces lasaliensis was determined to study the biochemistry and regulation of antibiotic biosynthesis in vivo.

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Bibliographic Details
Published in:Journal of antibiotics 1986, Vol.39(9), pp.1270-1280
Main Authors: SHERMAN, MARY M., HUTCHINSON, C. RICHARD
Format: Article
Language:English
Subjects:
Antibiotics
Biological and medical sciences
Biotechnology
Cerulenin - pharmacology
Cycloheximide - pharmacology
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
Lasalocid - biosynthesis
p-Fluorophenylalanine - pharmacology
Production of active biomolecules
Propionates - pharmacology
Streptomyces - metabolism
Succinates - pharmacology
Succinic Acid
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Description
Summary:The effect of known precursors, their fluorinated analogs, and biochemical inhibitors on the production of the polyether antibiotic, lasalocid A (1), by resting cells of Streptomyces lasaliensis was determined to study the biochemistry and regulation of antibiotic biosynthesis in vivo.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.39.1270