Bioavailability of Mefenamic Acid: Influence of Food and Water Intake

The influence of food and water intake on mefenamic acid (N-2, 3-xylylanthranilic acid) bioavailability from commercial capsules of high bioavailability was studied in four healthy male volunteers. The drug was administered as a single oral dose of 250mg, under fasting or nonfasting conditions, and...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1986-09, Vol.75 (9), p.891-893
Main Authors: Hamaguchi, Tsuneo, Shinkuma, Denji, Yamanaka, You, Mizuno, Nobuyasu
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biological Availability
Drinking
Eating
General pharmacology
Humans
Intestinal Absorption
Male
Medical sciences
Mefenamic Acid - blood
Mefenamic Acid - metabolism
Middle Aged
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
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Summary:The influence of food and water intake on mefenamic acid (N-2, 3-xylylanthranilic acid) bioavailability from commercial capsules of high bioavailability was studied in four healthy male volunteers. The drug was administered as a single oral dose of 250mg, under fasting or nonfasting conditions, and a 4 × 4 Latin-square design was used. Eight blood samples were collected over a 24-h period following drug administration, and the drug plasma concentrations were determined by HPLC. The bioavailability of mefenamic acid from capsules was markedly influenced in the fasting subjects by the water but not by the food intake. A good correlation was found between the bioavailability and amount of water ingested with the drug in the fasting subjects. The area under the plasma concentration-time curve (AUCo-∞ of mefenamic acid was highest when the capsule was taken with 50mL of water or immediately after a meal. Increasing the amount of water from 50 to 500mL in the fasting subjects caused a significant reduction in AUCo-∞.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600750914