Involvement of chromosome 22 in ependymomas

We have karyotyped a total of twelve ependymomas using GTG-banding including seven for which preliminary results have already been published. One case showing hyperdiploid main line with two marker chromosomes was further analyzed by nonisotopic chromosome in situ suppression hybridization. It was s...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 1995-02, Vol.79 (2), p.173-176
Main Authors: Wernicke, Catrin, Thiel, Gundula, Lozanova, Tanka, Vogel, Siegfried, Kintzel, Dieter, Jänisch, Werner, Lehmann, Karin, Witkowski, Regine
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Brain Neoplasms - genetics
Child
Child, Preschool
Chromosomes, Human, Pair 22
Ependymoma - genetics
Female
Humans
In Situ Hybridization, Fluorescence
Infant
Karyotyping
Male
Medical sciences
Middle Aged
Neurology
Tumors of the nervous system. Phacomatoses
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Summary:We have karyotyped a total of twelve ependymomas using GTG-banding including seven for which preliminary results have already been published. One case showing hyperdiploid main line with two marker chromosomes was further analyzed by nonisotopic chromosome in situ suppression hybridization. It was shown that the marker chromosomes consisted of 1q, 14q and 1q, and 22q. The possible role of chromosome 22 in ependymomas and the usefulness of fluorescence in situ hybridization for cytogenetic analysis in tumor investigation are discussed.
ISSN:0165-4608
1873-4456
DOI:10.1016/0165-4608(94)00148-5