Kadsuralignans H−K from Kadsura coccinea and Their Nitric Oxide Production Inhibitory Effects

One new arylnaphthalene lignan named kadsuralignan H (1) and three new dibenzocyclooctadiene lignans, named kadsuralignans I (2), J (3), and K (4), respectively, were isolated from an EtOAc fraction of the 80% acetone extract of Kadsura coccinea. The structures were elucidated on the basis of spectr...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2007-12, Vol.70 (12), p.1999-2002
Main Authors: Li, Heran, Wang, Liyan, Yang, Zhigang, Kitanaka, Susumu
Format: Article
Language:English
Subjects:
Animals
anti-inflammatory activity
Biological and medical sciences
chemical structure
cultured cells
Cyclooctanes - chemistry
Cyclooctanes - isolation & purification
Cyclooctanes - pharmacology
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - isolation & purification
Drugs, Chinese Herbal - pharmacology
General pharmacology
human health
Interferon-gamma - pharmacology
Kadsura
Kadsura - chemistry
Kadsura coccinea
kadsuralignan
lignans
Lignans - chemistry
Lignans - isolation & purification
Lignans - pharmacology
Lipopolysaccharides - pharmacology
macrophages
Macrophages - drug effects
Medical sciences
medicinal plants
medicinal properties
Mice
Molecular Structure
naphthalene
nitric oxide
Nitric Oxide - antagonists & inhibitors
Nitric Oxide - biosynthesis
Oriental traditional medicine
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plants, Medicinal - chemistry
spectral analysis
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Summary:One new arylnaphthalene lignan named kadsuralignan H (1) and three new dibenzocyclooctadiene lignans, named kadsuralignans I (2), J (3), and K (4), respectively, were isolated from an EtOAc fraction of the 80% acetone extract of Kadsura coccinea. The structures were elucidated on the basis of spectroscopic evidence. Compound 1 is the second arylnaphthalene lignan isolated from the Kadsura genus. Compounds 1 and 3 showed inhibitory activity on nitric oxide (NO) production by the murine macrophage-like cell RAW264.7, which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-γ (INF-γ).
ISSN:0163-3864
1520-6025
DOI:10.1021/np070269x