Kadsuralignans H−K from Kadsura coccinea and Their Nitric Oxide Production Inhibitory Effects

• Published in: Journal of natural products (Washington, D.C.) D.C.), 2007-12, Vol.70 (12), p.1999-2002
• Main Authors: Li, Heran, Wang, Liyan, Yang, Zhigang, Kitanaka, Susumu
• Format: Article
• Language: English
• Subjects: Animals; anti-inflammatory activity; Biological and medical sciences; chemical structure; cultured cells; Cyclooctanes - chemistry; Cyclooctanes - isolation & purification; Cyclooctanes - pharmacology; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - isolation & purification; Drugs, Chinese Herbal - pharmacology; General pharmacology; human health; Interferon-gamma - pharmacology; Kadsura; Kadsura - chemistry; Kadsura coccinea; kadsuralignan; lignans; Lignans - chemistry; Lignans - isolation & purification; Lignans - pharmacology; Lipopolysaccharides - pharmacology; macrophages; Macrophages - drug effects; Medical sciences; medicinal plants; medicinal properties; Mice; Molecular Structure; naphthalene; nitric oxide; Nitric Oxide - antagonists & inhibitors; Nitric Oxide - biosynthesis; Oriental traditional medicine; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plants, Medicinal - chemistry; spectral analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np070269x

One new arylnaphthalene lignan named kadsuralignan H (1) and three new dibenzocyclooctadiene lignans, named kadsuralignans I (2), J (3), and K (4), respectively, were isolated from an EtOAc fraction of the 80% acetone extract of Kadsura coccinea. The structures were elucidated on the basis of spectroscopic evidence. Compound 1 is the second arylnaphthalene lignan isolated from the Kadsura genus. Compounds 1 and 3 showed inhibitory activity on nitric oxide (NO) production by the murine macrophage-like cell RAW264.7, which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-γ (INF-γ).