Pollen-related allergy to peach and apple: An important role for profilin

Background: Birch pollinosis is often accompanied by allergy to fruits such as peach and apple. Bet v I is of major importance as cross-reactive allergen for this combined allergy. We studied a group of patients with combined grass pollinosis and fruit allergy from an area virtually without birch tr...

Full description

Saved in:
Bibliographic Details
Published in:Journal of allergy and clinical immunology 1995-03, Vol.95 (3), p.726-734
Main Authors: van Ree, Ronald, Fernández-Rivas, Montserrat, Cuevas, Manuela, van Wijngaarden, a, Michiel, Aalberse, Rob C.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Allergens - immunology
Allergic diseases
Bet v I
Biological and medical sciences
carbohydrate
Contractile Proteins
Cross Reactions
cross-reactivity
Female
Fruit - immunology
fruit allergy
Humans
Hypersensitivity - etiology
Immunoblotting
Immunoglobulin E - blood
Immunoglobulin E - immunology
Immunopathology
Male
Medical sciences
Microfilament Proteins - immunology
Other localizations
Plant Proteins - immunology
Pollen - immunology
Pollinosis
profilin
Profilins
Prunus persica
Radioallergosorbent Test
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Birch pollinosis is often accompanied by allergy to fruits such as peach and apple. Bet v I is of major importance as cross-reactive allergen for this combined allergy. We studied a group of patients with combined grass pollinosis and fruit allergy from an area virtually without birch trees. Objective: The aim of this study was to investigate the possible involvement of profilin and carbohydrate groups as cross-reactive structures in pollen and fruits. Methods: RAST inhibition was performed to measure cross-reactive IgE to pollen and fruits. The presence of IgE against profilin was determined in a RAST with purified grass profilin, and IgE against carbohydrate structures was determined in a RAST with proteinase K–digested grass pollen extract. The biologic activity of IgE in response to profilin was tested by in vitro histamine release and skin prick tests. Results: IgE against fruits was shown to be largely cross-reactive with grass pollen. The majority of the patients had IgE against profilin (12 of 16) and carbohydrate structures (9 of 10). Profilin was shown to have biologic activity, in both histamine release and skin prick tests. Conclusion: Profilin is an important allergen for patients with combined grass pollen/fruit allergy in areas without birch trees. (J A LLERGY C LIN I MMUNOL 1995;95:726-34.)
ISSN:0091-6749
1097-6825
DOI:10.1016/S0091-6749(95)70178-8